He Tumanako Hou mō te Lymphoma Pūtau-B Ātete-Chemotherapy: He Hua Pai te Whakaora CAR-T
Kua whakaatuhia e ngā rangahau tata nei te kaha o te rongoā pūtau-T Chimeric Antigen Receptor (CAR) ki te rongoā i ngā tūroro e pangia ana e ngā mate pukupuku pūtau-B e kore e pai ki te chemotherapy, inā koa ko ngā mate pukupuku nui e horapa ana. Lymphoma Pūtau-B (DLBCL) me ngā lymphoma pūtau-B mangere. Ko tēnei rangahau hou, i whakaputaina i roto i teTe Pukapuka o te Matepukupuku Hauora, e kī ana he whanaketanga nui pea te rongoā CAR-T mō ngā tūroro kua pau ngā huarahi maimoatanga tuku iho.
I roto i te rangahau, i whiwhi tētahi rōpū o te 15 tūroro he mate pukupuku pūtau-B matatau i te rongoā CAR-T i muri i te whiwhinga i te rongoā chemotherapy whakatikatika. He mea whakamiharo, neke atu i te haurua o ēnei tūroro i tutuki te murunga katoa (CR), tae atu ki te whā o roto i te whitu o ngā tūroro ka taea te arotake me te DLBCL ātete-haumi. He tino pai ngā hua, me ētahi tūroro e mau tonu ana te CR mō te 22 marama.
Ko te mahi a te rongoā CAR-T mā te whakarerekē ira i ngā pūtau-T o te tūroro kia whakaatu i tētahi kaiwhakawhiwhi anti-CD19, ka arotahi ki ngā pūtau-B mate pukupuku, ka whakangaro hoki. I kitea i roto i te rangahau kāore i te taea anake tēnei huarahi engari he tino whai hua hoki ki te whakaputa i ngā murunga roa. Heoi, kāore i te kore he wero mō te rongoā. I kitea ngā paitini whakapeka, pērā i te cytokine release syndrome me te neurotoxicity, ahakoa i taea te whakahaere i ēnei me te whakatau i roto i ētahi wiki.
I whakanui a Tākuta J. Kochenderfer, tētahi o ngā kairangahau matua, i te hiranga o ēnei kitenga, me te kī, "Koinei te pūrongo tuatahi mō te angitu o te maimoatanga o te DLBCL me ngā pūtau anti-CD19 CAR-T, ā, ka huaki te kuaha mō te whanaketanga tonu o tēnei huarahi."
He tumanako hou kei roto i ngā kitenga o te rangahau mō ngā tūroro he uaua ki te whiwhi i ngā lymphoma pūtau-B, he iti noa iho ngā whiringa maimoatanga i mua, ā, he kino hoki ngā putanga. I te whanaketanga tonu o te rongoā CAR-T, tera pea ka noho hei maimoatanga paerewa mō ngā momo mate pukupuku pūtau-B, ka noho hei oranga mō te hunga e whawhai ana ki ēnei mate pukupuku kaha.