Litaba

Nyeoeng ea pele ea bongaka, mokuli ea lilemo li 21 o ile a atleha ho hlōla liphephetso tsa thalassemia ka phekolo ea liphatsa tsa lefutso e tsoetseng pele e thehiloeng ho CRISPR. Mokhoa ona o mocha o tšoaea ntlha ea bohlokoa kalafong ea mafu a tebileng a mali a kang lefu la sele e sickle (SCD) le thalassemia.

Kopanong e tlang ea ASH 2024, sehlopha sa bongaka sa Sepetlele sa Lu Daopei se tla hlahisa liphuputso tse 13 tse ikhethang, tse totobatsang tsoelo-pele thutong ea mali le bokhoni ba phekolo ea CAR-T, ho tiisa boitlamo ba bona ba ho ntlafatsa liphetho tsa bakuli.

Kamora ho loana le lymphoma ka lilemo tse tharo, mosali ea lilemo li 61 o ile a fumana pholiso e felletseng ka kalafo e ncha ea CAR-T e habeli ho BIOOCUS, e bonts'ang bokhoni ba ho fetola bophelo ba kalafo e tsoetseng pele ea mofetše.

Tsoelo-pele ea morao tjena theknolojing ea CRISPR/Cas e fetola boemo ba ho hlophisa liphatsa tsa lefutso lipatlisisong tsa bongaka. Sengoloa sena se hlahloba ts'ebeliso ea sona, se totobatsa monyetla o moholo oa ho phekola mafu a liphatsa tsa lefutso, mofetše le mafu a tšoaetsanoang.

Nyeoe e ikhethang ho BIOOCUS e bonts'a tšusumetso e fetolang ea phekolo ea CD7 CAR-T ho moshanyana ea lilemo li 15 ea nang le leukemia ea T-cell acute lymphoblastic (T-ALL) e khutlileng hape, e lebisang pholisong e felletseng le ho kenngoa ha setho sa bobeli ka katleho.

Bioocus e thabetse ho kenela Kopano ya bo8 ya Kalafo ya Immuno-Gene le Cell (IGC 2024)! Re labalabela ho sebelisana le ditsebi tsa lefatshe le ho hlahloba mehlala e metjha ya kgwebo e tsamaellanang le mahlale a morao-rao a kalafo ya liphatsa tsa lefutso le sele. Mmoho, ha re bopeng bokamoso ba kalafo ya immunotherapy.

Sehlooho sena sa litaba se totobatsa lipatlisiso tsa morao tjena mabapi le ho laola chefo ea phekolo ea lisele tsa CAR-T bakeng sa li-lymphoma tsa B-cell. Phuputso ena e totobatsa maano a ho sebetsana le litla-morao tse tloaelehileng joalo ka cytokine release syndrome (CRS) le neurotoxicity (ICANS), ho netefatsa tšebeliso e sireletsehileng ea kalafo ena e ncha.

Phuputso ea morao-rao e totobatsa katleho le polokeho ea phekolo ea lisele tsa CD7 CAR-T ho phekoleng leukemia ea B-cell acute lymphoblastic (B-ALL) e khutlileng kapa e sa laoleheng le T-cell lymphoblastic lymphoma (T-LBL). Phuputso ena, e entsoeng ke BIOOCUS ka tšebelisano-'moho le Sepetlele sa Lu Daopei, e bontša liphello tse tšepisang bakeng sa bakuli, e fana ka mokhoa o mong o matla ho feta chemotherapy ea setso.

Phuputso ena, e phatlalalitsoeng ho Koranta ea Oncology ea Bongaka, e bonts'a sekhahla se seholo sa pholiso ho bakuli ba neng ba se ba qetile mekhoa ea phekolo ea setso, e leng se tšoaeang tsoelo-pele e tšepisang phekolong ea kankere.

Phuputso ea morao tjena e totobatsa katleho ea phekolo ea CD7 CAR-T e lateloang ke phetisetso ea bobeli ea lisele tsa hematopoietic stem (HSCT) ho bakuli ba nang le leukemia ea T-cell acute lymphoblastic leukemia (T-ALL) e khutlisitsoeng hape le lymphoblastic lymphoma (LBL), e bonts'ang bokhoni bo boholo ba ho fihlela pholiso e felletseng ea lefu le saletseng (MRD) le le saletseng morao.

Phuputso e ncha e bonts'a katleho ea nako e telele ea phekolo ea lisele tsa CD19 CAR T ho phekoleng bakuli ba nang le leukemia ea lymphoblastic e khutlang hape/e sa pheleng hantle (ALL) kamora ho kenngoa ha lisele tsa stem tsa hematopoietic allogeneic, e fanang ka tšepo e ncha thutong ea mali.

Bioocus e etella pele ho nts'etsapele mekhoa ea phekolo ea CAR-T ea moloko o latelang. Khatiso ea morao tjena ea Dr. Chunrong Tong le sehlopha sa hae Sepetleleng sa Lu Daopei e totobatsa tsoelo-pele ea bohlokoa le liphephetso ts'ebelisong ea mekhoa ea phekolo ea CD19 CAR-T ea moloko oa bobeli ho bakuli ba bana, e bonts'a boitlamo ba Bioocus kalafong e ncha ea mofetše.