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Ho Hlōla Lymphoma ka Kalafo e 'Meli ea CAR-T

2024-09-27

Mosadi wa dilemo tse 61, ya neng a ile a mamella kalafo tse ngata tsa diffuse large Lymphoma ea Lisele tsa B, ho kenyeletsoa le lipotoloho tse supileng tsa chemotherapy, phekolo ea CAR-T, le lipotoloho tse ngata tsa PD-1 chemotherapy le mahlaseli a kopantsoeng, li ile tsa iphumana li le kotsing. Ho sa tsotellehe boiteko ba hae, boemo ba hae bo ile ba bontša ntlafatso e nyane ho fihlela a fihla BIOOCUS bakeng sa tlhokomelo e khethehileng.

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Mathoasong a 2021, kaha lymphoma ea hae e ntse e tsoela pele ka potlako 'me e baka liso tse matla letlalong le ho ruruha, boemo ba mokuli bo ne bo bonahala bo le bobe. Tlas'a tlhokomelo ea sehlopha se inehetseng ho BIOOCUS, o ile a qala leeto le lecha la kalafo. Kamora kalafo ea pele, boemo ba hae bo ile ba tsitsa, e leng se ileng sa lebisa ho bokelloeng le ho lengoeng ha li-lymphocyte tsa hae bakeng sa kalafo ea lisele tsa CD19/CD22 CAR-T.

Ka la 19 Hlakola 2021, o ile a fumana pheko ea lisele tse peli tsa CAR-T. Leha a bile le litla-morao tse laolehang, litlhahlobo tse latelang tsa PET-CT li ile tsa senola ntlafatso e kholo. Ka Hlakubele, o ile a fihlela pholiso e batlang e le ka ho feletseng, e leng se ileng sa tšoaea phetoho ntoeng ea hae khahlanong le mofetše.

Jwale, dilemo tse tharo kamora kalafo ya CAR-T, o arolelana pale ya hae ya ho fola ka mafolofolo ho Fourth Lymphoma ea Chaena Seboka sa Bakuli, se khothatsang ba bang ba tobaneng le mathata a tšoanang. Leeto la hae le totobatsa tsoelo-pele ea mekhoa ea phekolo ea CAR-T le karolo ea bohlokoa ea meriana e ikhethileng ho phekoleng li-lymphoma tse rarahaneng.

Ka lebaka la tlhokomelo e felletseng ho BIOOCUS, o ntse a tsoela pele ho atleha, a hatisa bohlokoa ba mekhoa e mecha ea phekolo le tšehetso ea litsebi tse inehetseng tsa tlhokomelo ea bophelo ho hlōleng kankere.