Ukunqoba i-Lymphoma nge-Dual CAR-T Therapy

Owesifazane oneminyaka engu-61 ubudala, owayesebekezelele ukwelashwa okuningi kwe-diffuse large I-B-Cell Lymphoma, okuhlanganisa imijikelezo eyisikhombisa ye-chemotherapy, ukwelashwa kwe-CAR-T, kanye nemijikelezo eminingi ye-PD-1 chemotherapy ehlanganisiwe kanye nemisebe, wazithola esengozini. Naphezu kwemizamo yakhe, isimo sakhe asizange sibonise ukuthuthuka kwaze kwaba yilapho efika e-BIOOCUS ukuze athole ukunakekelwa okukhethekile.

Ekuqaleni kuka-2021, njengoba i-lymphoma yakhe ikhula ngokushesha futhi ibangela izilonda zesikhumba ezinzima kanye nokuvuvukala, isimo sesiguli sabonakala sibi kakhulu. Ngaphansi kokunakekelwa yithimba elizinikele kwa-BIOOCUS, waqala uhambo olusha lokwelashwa. Ngemva kokwelashwa kokuqala, isimo sakhe sazinza, okwaholela ekuqoqweni nasekukhulisweni kwama-lymphocyte akhe ukuze asetshenziswe ekwelashweni kwamaseli e-CD19/CD22 CAR-T.

Ngomhlaka-19 kuNhlolanja 2021, wathola ukumnika amaseli e-CAR-T amabili. Nakuba abhekana nemiphumela emibi elawulekayo, ukuskena kwe-PET-CT okwalandela kwaveza intuthuko enkulu. NgoMashi, wafinyelela ukuphulukiswa okucishe kube okuphelele, okwaphawula ukuguquka empini yakhe nomdlavuza.

Manje, eminyakeni emithathu ngemuva kokwelashwa kwe-CAR-T, wabelana ngentshiseko ngendaba yakhe yokululama eSikhungweni Sesine. I-China Lymphoma Ingqungquthela Yeziguli, ekhuthaza abanye ababhekene nezinselele ezifanayo. Uhambo lwakhe lugcizelela intuthuko kwezokwelapha ze-CAR-T kanye nendima ebalulekile yemithi eyenzelwe wena ekwelapheni ama-lymphoma ayinkimbinkimbi.

Ngenxa yokunakekelwa okuphelele kwa-BIOOCUS, uyaqhubeka nokuchuma, egcizelela ukubaluleka kokwelashwa okusha kanye nokusekelwa kochwepheshe bezempilo abazinikele ekunqobeni umdlavuza.