Ukoyisa iLymphoma ngeDual CAR-T Therapy

Umfazi oneminyaka engama-61 ubudala, owayenyamezele unyango oluninzi lwe-diffuse large I-B-Cell Lymphoma, kuquka imijikelo esixhenxe yechemotherapy, unyango lwe-CAR-T, kunye nemijikelo emininzi ye-PD-1 combined chemotherapy kunye ne-radiation, wazifumana ekwindawo ekunzima ukuyifikelela. Nangona wayezama, imeko yakhe ayizange ibonakalise ukuphucuka okukhulu de wafika kwi-BIOOCUS ukuze afumane unyango olukhethekileyo.

Ekuqaleni kuka-2021, njengoko i-lymphoma yakhe yayisiya isanda ngokukhawuleza kwaye ibangela izilonda ezinkulu zesikhumba kunye nokudumba, imeko yesigulana yabonakala imbi kakhulu. Phantsi kokhathalelo lweqela elizinikeleyo kwi-BIOOCUS, waqala uhambo olutsha lonyango. Emva konyango lokuqala, imeko yakhe yazinza, nto leyo eyakhokelela ekuqokeleleni nasekukhuliseni ii-lymphocytes zakhe ukuze zisetyenziswe kunyango lweeseli ze-CD19/CD22 CAR-T.

Ngomhla we-19 kweyoMdumba ngo-2021, wafumana i-dual CAR-T cell infusion. Nangona wafumana iziphumo ebezingalindelekanga ezilawulekayo, ii-PET-CT scans ezalandelayo zabonisa ukuphucuka okukhulu. NgoMatshi, wafumana ukuphumla okuphantse kwaphela, nto leyo eyaphawula utshintsho olukhulu kumlo wakhe nxamnye nomhlaza.

Ngoku, emva kweminyaka emithathu emva konyango lwe-CAR-T, wabelana ngebali lakhe lokuchacha kwi-Fourth I-China Lymphoma INkomfa yeSigulana, ekhuthaza abanye abajongene nemingeni efanayo. Uhambo lwakhe lugxininisa inkqubela phambili kunyango lwe-CAR-T kunye nendima ebalulekileyo yonyango lomntu ngamnye ekunyangeni ii-lymphomas ezintsonkothileyo.

Ngenxa yokhathalelo olupheleleyo kwi-BIOOCUS, uyaqhubeka echuma, egxininisa ukubaluleka konyango olutsha kunye nenkxaso yeengcali zezempilo ezizinikeleyo ekulweni nomhlaza.