Ubuvuzi bwa CD19 CAR-T bwo mu bitaro bya Lu Daopei bwagaragaje umusaruro mwiza ku barwayi ba B-ALL
Mu bushakashatsi bw’ibanze bwakorewe mu bitaro bya Lu Daopei, abashakashatsi batangaje iterambere rikomeye mu kuvura kanseri y’amaraso ya B acute lymphoblastic leukemia (B-ALL) idashobora kugaragara cyangwa yasubiwemo hakoreshejwe uburyo bwo kuvura bwa CD19-directed CAR-T cells bukoresha CD19. Ubu bushakashatsi bwakorewe ku barwayi 51, bwagaragaje ko ubu buryo bushya butageze ku gipimo cyo hejuru cyo kugabanya burundu indwara (CR) gusa ahubwo bunagumana umutekano mwiza.
Itsinda ry’ubushakashatsi, riyobowe na Dr. C. Tong wo mu ishami ry’ubuvuzi bw’amaraso na Dr. AH Chang wo mu kigo cy’ubushakashatsi mu buhinduzi bw’imiti muri Kaminuza ya Tongji, ryakoze ubushakashatsi ku ngaruka zo gutanga dose ntoya ya CAR-T—hafi 1 × 10^5/kg—ugereranije n’idose isanzwe yo hejuru. Ubu buryo bwari bugamije kuringaniza imikorere myiza yo kuvura no kugabanya ingaruka mbi cyane, cyane cyane indwara yo gusohora cytokine (CRS).
Ibisubizo by’ubushakashatsi byari bishimishije. Mu barwayi 42 ba B-ALL basubijemo/basubijemo, 36 bagezeho CR cyangwa CR bakize umubare utuzuye (CRi), mu gihe abarwayi icyenda bose bafite indwara ntoya isigara (MRD) bageze ku ndunduro ya MRD. Byongeye kandi, abarwayi benshi bahuye na CRS yoroheje kugeza ku iringaniye, aho indwara zikomeye zavurwaga neza binyuze mu ngamba zo gufasha hakiri kare.
Dr. Tong yagaragaje akamaro k'ubu bushakashatsi, agira ati: "Ibisubizo bigaragaza ko uburyo bwo kuvura CD19 CAR-T hakoreshejwe dose nke, hanyuma hagakurikiraho uburyo bwo gutera uturemangingo tw’amaraso mu maraso (allo-HCT), butanga uburyo bwiza cyane bwo kuvura abarwayi bafite ubundi buryo buke. Ubu buryo ntibutanga gusa uburyo bwo kuvura bwinshi ahubwo bunagabanya cyane ibyago byo kugira ingaruka mbi zikomeye."
Intsinzi y'ubu bushakashatsi igaragaza ubushobozi bw'ubuvuzi bwa CAR-T bukozwe mu kuvura kanseri ikomeye y'amaraso. Ibitaro bya Lu Daopei, bizwiho akazi ka mbere mu kuvura kanseri zifata ingirabuzimafatizo. Ubudahangarwa bw'umubiri, ikomeje kuyobora mu gutanga ubuvuzi bugezweho ku barwayi bafite ibibazo bikomeye by’amaraso.
Uko ubushakashatsi bukomeza, itsinda ry’abashakashatsi rifite icyizere cyo gukomeza kunoza ingano n’amabwiriza kugira ngo bongere umusaruro w’abarwayi. Ibyavuye muri ubu bushakashatsi byasohotse mu kinyamakuru. Leukemia kandi bitanga icyizere cy'icyizere ku barwayi ba B-ALL ku isi yose.