Hōʻike ka lāʻau lapaʻau CD19 CAR-T haʻahaʻa o ka haukapila ʻo Lu Daopei i nā hopena maikaʻi i nā poʻe maʻi B-ALL
Ma kahi noiʻi hou i mālama ʻia ma ka Halemai ʻo Lu Daopei, ua hōʻike nā kānaka noiʻi i nā holomua koʻikoʻi i ka mālama ʻana i ka leukemia lymphoblastic B acute refractory a i ʻole relapsed (B-ALL) me ka hoʻohana ʻana i ka lāʻau lapaʻau cell CAR-T haʻahaʻa CD19. Ua hōʻike ka noiʻi, i pili i 51 mau maʻi, ʻaʻole i loaʻa i kēia ala hana hou nā helu hoʻomaha piha (CR) kiʻekiʻe akā ua mālama pū i kahi ʻano palekana maikaʻi.
Ua noiʻi ka hui noiʻi, i alakaʻi ʻia e Kauka C. Tong mai ke Keʻena Hematology a me Kauka AH Chang mai ke Kikowaena Noiʻi Hoʻololi Lapaʻau ma ke Kula Lapaʻau o ke Kulanui ʻo Tongji, i nā hopena o ka hāʻawi ʻana i kahi mahele haʻahaʻa o nā pūnaewele CAR-T—ma kahi o 1 × 10^5/kg—i hoʻohālikelike ʻia me nā mahele kiʻekiʻe maʻamau. ʻO ka pahuhopu o kēia ʻano hana ke kaulike i ka pono therapeutic me ka hōʻemi ʻana i nā hopena ʻaoʻao koʻikoʻi, ʻoiai ka cytokine release syndrome (CRS).
He mea hoihoi nā hopena o ke aʻo ʻana. Ma waena o nā maʻi B-ALL 42 i hoʻopaʻakikī/hoʻi hou, 36 i loaʻa iā CR a i ʻole CR me ka hoʻōla helu piha ʻole (CRi), ʻoiai ʻo nā maʻi ʻeiwa me ka maʻi koena liʻiliʻi (MRD) i hōʻea i ka MRD negativity. Eia kekahi, ʻo ka hapa nui o nā maʻi i loaʻa wale i ka CRS akahai a kaulike, me nā hihia koʻikoʻi i mālama pono ʻia ma o nā hoʻolālā hana mua.
Ua hōʻike ʻo Kauka Tong i ke koʻikoʻi o kēia haʻawina, me ka ʻōlelo ʻana, "Hōʻike nā hopena i ka lāʻau lapaʻau haʻahaʻa CD19 CAR-T cell, a ukali ʻia e ka allogeneic hematopoietic stem cell transplantation (allo-HCT), hāʻawi i kahi koho lapaʻau kūpono loa no nā poʻe maʻi i kaupalena ʻia nā koho ʻē aʻe. ʻAʻole wale kēia lāʻau lapaʻau e hāʻawi i nā helu pane kiʻekiʻe akā hoʻohaʻahaʻa nui hoʻi i ka pilikia o nā hopena maikaʻi ʻole."
ʻO ka holomua o kēia haʻawina e hōʻike ana i ka hiki o nā lāʻau lapaʻau CAR-T i hana kūikawā ʻia i ka mālama ʻana i nā maʻi hematological paʻakikī. ʻO ka Halemai ʻo Lu Daopei, kaulana no kāna hana paionia ma ke kelepona Hoʻōla lāʻau pale, ke hoʻomau nei i ke alakaʻi ʻana i ka hāʻawi ʻana i nā lāʻau lapaʻau ʻoi loa no nā poʻe maʻi me nā kūlana hematologic paʻakikī.
I ka holomua ʻana o ke aʻo ʻana, ua manaʻolana ka hui noiʻi e pili ana i ka hoʻomaikaʻi hou ʻana i ka lāʻau a me nā protocols e hoʻomaikaʻi i nā hopena o ka mea maʻi. Ua paʻi ʻia nā ʻike mai kēia aʻo ʻana ma ka puke pai. Leukemia a hāʻawi i kahi hiʻohiʻona manaʻolana no nā poʻe maʻi B-ALL ma ka honua holoʻokoʻa.