Maganin CAR-T na Asibitin Lu Daopei mai ƙarancin allurai na CD19 ya nuna sakamako mai kyau ga marasa lafiya na B-ALL.

A wani bincike mai zurfi da aka gudanar a Asibitin Lu Daopei, masu bincike sun bayar da rahoton ci gaba mai mahimmanci a fannin maganin cutar sankarar jini ta B mai saurin kamuwa da cutar sankarar jini ta B (B-ALL) ta amfani da maganin ƙwayoyin CAR-T mai ƙarancin allurai na CD19. Binciken, wanda ya ƙunshi marasa lafiya 51, ya nuna cewa wannan sabuwar hanyar ba wai kawai ta cimma babban adadin sassauci (CR) ba, har ma ta ci gaba da kasancewa mai kyau ga lafiya.

Ƙungiyar binciken, ƙarƙashin jagorancin Dr. C. Tong daga Sashen Ilimin Jini da Dr. AH Chang daga Cibiyar Bincike ta Fassarar Asibiti a Makarantar Likitanci ta Jami'ar Tongji, sun binciki tasirin bayar da ƙananan allurai na ƙwayoyin CAR-T—kimanin 1 × 10^5/kg—idan aka kwatanta da allurai mafi girma na yau da kullun. Wannan hanyar tana da nufin daidaita tasirin magani tare da rage mummunan tasirin, musamman cutar sakin cytokine (CRS).

Sakamakon binciken ya kasance mai ban sha'awa. Daga cikin marasa lafiya 42 da suka yi fama da rashin lafiya/masu fama da cutar B-ALL, 36 sun sami CR ko CR tare da murmurewa daga ƙididdigewa (CRi), yayin da dukkan marasa lafiya tara da ke fama da ƙarancin cutar da ta rage (MRD) suka kai ga rashin lafiyar MRD. Bugu da ƙari, yawancin marasa lafiya sun sami CRS mai sauƙi zuwa matsakaici kawai, tare da magance manyan lamuran da suka shafi yadda ya kamata ta hanyar dabarun shiga tsakani da wuri.

Dr. Tong ya nuna muhimmancin wannan binciken, yana mai cewa, "Sakamakon ya nuna cewa maganin ƙwayoyin CD19 CAR-T mai ƙarancin allurai, sannan dashen ƙwayoyin halittar jini na allogeneic (allo-HCT), yana ba da zaɓi mai inganci ga marasa lafiya waɗanda ke da wasu zaɓuɓɓuka masu iyaka. Wannan maganin ba wai kawai yana ba da babban adadin amsawa ba ne, har ma yana rage haɗarin mummunan sakamako."

Nasarar wannan binciken ta nuna yuwuwar magungunan ƙwayoyin CAR-T da aka tsara musamman wajen magance cututtukan hanta masu sarkakiya. Asibitin Lu Daopei, wanda aka san shi da aikinsa na farko a fannin ƙwayoyin halitta. Maganin rigakafi, yana ci gaba da jagorantar samar da magunguna na zamani ga marasa lafiya da ke fama da matsalolin cututtukan jini.

Yayin da binciken ke ci gaba, ƙungiyar masu binciken tana da kyakkyawan fata game da ƙara inganta yawan magani da ƙa'idodi don inganta sakamakon marasa lafiya. An buga sakamakon wannan binciken a cikin mujallar. Cutar sankarar bargo kuma suna samar da kyakkyawan fata ga marasa lafiya na B-DUKA a duk duniya.