Kurapa kweLu Daopei kweCD19 CAR-T kwaratidza mhedzisiro yakanaka muvarwere veB-ALL
Muchidzidzo chitsva chakaitwa paLu Daopei Hospital, vaongorori vakataura nezvekufambira mberi kukuru mukurapa refractory kana relaxated B acute lymphoblastic leukemia (B-ALL) vachishandisa CD19-directed CAR-T cell therapy ine dose shoma. Chidzidzo ichi, chaisanganisira varwere makumi mashanu nerimwe, chakaratidza kuti nzira iyi itsva haina kungowana huwandu hwepamusoro hwe relievement (CR) asi yakachengetedzawo kuchengetedzeka kwakanaka.
Chikwata chekutsvagisa, chaitungamirwa naDr. C. Tong wekuDhipatimendi reHematology naDr. AH Chang wekuClinical Translational Research Center paTongji University School of Medicine, chakaongorora migumisiro yekupa masero eCAR-T dose shoma—inenge 1 × 10^5/kg—zvichienzaniswa nedose yepamusoro yakajairika. Nzira iyi yaivavarira kuenzanisa kushanda kwekurapa nekuderedza migumisiro yakaipa, kunyanya cytokine release syndrome (CRS).
Zvakabuda muchidzidzo ichi zvaifadza. Pakati pevarwere makumi mana nevaviri vakadzokera shure muchirwere cheB-ALL, makumi matatu nevatanhatu vakawana CR kana CR vasina kupora zvakakwana (CRi), nepo varwere vapfumbamwe vese vane chirwere chidiki cheMRD (MRD) vakasvika pakusagadzikana kweMRD. Uyezve, varwere vazhinji vakasangana neCRS iri pakati nepakati, uye nyaya dzakakomba dzakabatwa zvinobudirira kuburikidza nematanho ekupindira nekukurumidza.
Dr. Tong vakaratidza kukosha kwechidzidzo ichi, vachiti, "Zvakabuda zvinoratidza kuti kurapwa kwemasero eCD19 CAR-T nedosi shoma, kunoteverwa ne allogeneic hematopoietic hematopoietic stem cell transplantation (allo-HCT), kunopa nzira yekurapa inoshanda zvikuru kune varwere vane dzimwe nzira shoma. Kurapa uku hakungopi mhinduro yepamusoro chete asiwo kunoderedza njodzi yemigumisiro yakaipa."
Kubudirira kwechidzidzo ichi kunoratidza mukana wekurapa masero eCAR-T akagadzirwa nemaoko mukurapa zvirwere zveropa. Chipatara cheLu Daopei, chinozivikanwa nebasa guru mukurapa zvirwere zveropa. Kurapa nekudzivirira muviri, inoramba ichitungamira mukupa mishonga yemazuva ano kune varwere vane matambudziko eropa akaoma.
Sezvo chidzidzo ichi chichienderera mberi, timu yevaongorori ine tariro yekuvandudza huwandu hwemushonga uye maitiro ekurapa kuti zviwedzere mhedzisiro yemurwere. Zvakawanikwa kubva muchidzidzo ichi zvakaburitswa mujenari. Leukemia uye kupa tariro kune varwere veB-ALL pasi rose.