MAPHUNZIRO A MLANDU ATSOPANO
CAR-T ya Glioblastoma
Glioblastoma ndi imodzi mwa matenda ofala kwambiri komanso ovuta kwambiri a khansa ya muubongo mwa akuluakulu. Imachokera ku maselo a glial muubongo ndipo imadziwika chifukwa cha kukula kwake mwachangu komanso chizolowezi chake cholowa m'minofu yozungulira, zomwe zimapangitsa kuti kuchotsa kwathunthu kukhale kovuta. Zizindikiro zake zitha kuphatikizapo mutu, khunyu, kusintha kwa malingaliro, komanso kusowa kwa mitsempha, kutengera komwe chotupacho chili. Ngakhale kuti chithandizo chokhazikika chingathandize kuthana ndi matendawa, odwala ambiri amafunafuna chithandizo cholunjika kuti apititse patsogolo zotsatira zake komanso moyo wawo.
Chithandizo cha CAR-T cha Khansa ya M'mimba
Chithandizo cha maselo a CAR-T ndi chithandizo chapamwamba kwambiri cha immunotherapy chomwe chikugwiritsidwa ntchito pochiza khansa ya m'mimba. BIOOCUS yapanga zinthu za CAR-T zomwe zimayang'ana ma antigen enieni a khansa ya m'mimba monga Claudin18.2 ndi HER2, zomwe zikuwonetsa kuti zimagwira ntchito bwino kwambiri kwa odwala omwe adalephera kulandira chithandizo cham'mbuyomu - mwachitsanzo, CT041 idapeza ORR ya 57.1%, DCR ya 75%, ndi chiwopsezo cha moyo wa miyezi 6 cha 81.2%. Pogwiritsa ntchito nsanja yapadziko lonse ya GMP, gulu la akatswiri osiyanasiyana, komanso chidziwitso chambiri chachipatala padziko lonse lapansi, BIOOCUS imapereka yankho lotetezeka, logwira mtima, komanso lokwanira la chithandizo cha CAR-T kwa odwala khansa ya m'mimba.
CAR-T ya Systemic Lupus Erythematosus (SLE)
Chithandizo cha maselo a CAR-T (Chimeric Antigen Receptor T) ndi njira yatsopano yochiritsira matenda yomwe yakhala ikugwira ntchito pochiza SLE polimbana ndi maselo a B, omwe amagwira ntchito yofunika kwambiri pakukula kwa matendawa. Mu SLE, maselo a B amapanga ma autoantibodies omwe amaukira minofu ya thupi, zomwe zimapangitsa kutupa kosatha komanso kuwonongeka kwa ziwalo. Chithandizo cha CAR-T chimagwira ntchito popanga maselo a T kuti awonetse cholandirira (CAR) chomwe chimayang'ana makamaka CD19, chizindikiro pa maselo a B, zomwe zimapangitsa kuti maselo a B owopsawa awonongeke.
Maselo a CAR-T omwe amalimbana ndi maselo a CD19+ B amapereka kuchepa kwa maselo a B kogwira mtima komanso kosatha poyerekeza ndi njira zina zochiritsira, zomwe zimalimbana ndi CD20 koma zimalephera kuchotsa maselo a m'magazi omwe amakhalapo kwa nthawi yayitali. Kuchepa kwakukulu kwa maselo a B kumeneku kungayambitse kuchira kwa zizindikiro za SLE mwa kuchotsa maselo omwe amachititsa kupanga ma antibodies a autoimmune. Kafukufuku amafufuzanso za CAR-Treg (maselo a CAR-T omwe adapangidwa kuti azilamulira mayankho a chitetezo chamthupi) kuti abwezeretse kulekerera kwa chitetezo chamthupi ndikuchepetsa ntchito ya chitetezo chamthupi.
FUCASO: Chithandizo cha Revolutionary Fully-Human BCMA CAR-T chokhala ndi Mphamvu ndi Chitetezo Chosayerekezeka
FUCASO ndi njira yatsopano yochiritsira matenda a CAR-T yochokera ku BCMA yochokera ku IASO BIO, yomwe imapereka mphamvu komanso chitetezo chosayerekezeka pa matenda a myeloma yambiri yomwe yabwereranso kapena yokana. Ndi kuchuluka kwa mayankho, kuchira kokhazikika, komanso chitetezo champhamvu, FUCASO imapereka chiyembekezo chatsopano kwa odwala ndikukhazikitsa muyezo watsopano mu chithandizo cha CAR-T.
Chidule Chathunthu cha Chithandizo Choopsa cha Khansa ya M'magazi
CAR-T Therapy, mwachidule Chimeric Antigen Receptor T-Cell Immunotherapy, ndi njira yapamwamba yochiritsira majini yomwe imaphatikizapo kusintha majini a T cells a wodwala kuti awononge maselo a khansa. Mosiyana ndi mankhwala achikhalidwe, CAR-T therapy imapangidwa kwa wodwala aliyense ndipo imafuna kusonkhanitsa maselo a T kuchokera m'magazi a wodwalayo asanawabwezeretse m'thupi pambuyo pa kusintha majini.