Bambo C----Diffuse Large B-cell Lymphoma (DLBCL)

Wodwala uyu, Bambo C, amachokera ku India ndipo ali ndi zaka 55. Kumayambiriro kwa chaka cha 2019, adadwala matenda a lymphadenopathy osatha ndipo adapita kuchipatala chathu. Kuwunika kwakukulu kunachitika, zomwe zidapangitsa kuti adziwe matenda a Diffuse Large B-Cell Lymphoma (DLBCL). Popeza DLBCL ndi yoopsa kwambiri, kuyamba kulandira chithandizo mwachangu kunali kofunikira kuti vutoli lithe bwino.

Asanalandire chithandizo cha CAR-T, a C adakumana ndi zochitika zingapo zachipatala zomwe zidaphatikizapo njira zosiyanasiyana zochiritsira chemotherapy. Poyamba, adalandira RCHOP ngati chithandizo choyamba, kenako adalandira chithandizo china kuphatikizapo REPOCH, R2-ICE, GEMOX-BTKi, Pola-BR, GB261, TQB2916, GA 101-Cedarbenamine-Doxil, ndipo pomaliza, Inotuzumab. Ngakhale kuti mankhwalawa adaperekedwa kwa nthawi yayitali ndipo adawonetsa mphamvu, adalephera kuthetsa matenda, zomwe zikuwonetsa kuti DLBCL ya a C inali yoopsa kwambiri.

Popeza kuti sanalandire chithandizo chokwanira chamankhwala ochiritsira komanso kuti matenda ake anali kupita patsogolo mofulumira, a C adadziwika kuti ndi omwe angalandire chithandizo cha maselo a CAR-T. Pambuyo pokonzekera mosamala, a C adapatsidwa chithandizo cha maselo a CAR-T kumayambiriro kwa chaka cha 2020. Njira yatsopano yochiritsira iyi ikuphatikizapo kusintha maselo a T a wodwala kuti azitha kuukira maselo a khansa moyenera.

Patatha masiku makumi awiri mphambu asanu ndi atatu kuchokera pamene maselo a CAR-T adabwezeretsedwanso, matenda ambiri adachira, zomwe zidawonetsa kupambana kwa chithandizocho. Zotsatirazi zidabweretsa chiyembekezo chatsopano kwa a C ndi gulu lawo lazaumoyo. Kuyankha kodabwitsa kwa chithandizo cha CAR-T kukuwonetsa kuthekera kwa chithandizo cha immunotherapy pochiza khansa yoopsa ya m'magazi monga DLBCL.

Patsogolo pake, a C adzayang'aniridwa nthawi zonse komanso kukaonana ndi dokotala kuti ayang'anire bwino matenda awo. Kuwongolera matenda kwa nthawi yayitali ndi kukhazikika ndizofunikira kwambiri pa dongosolo lake losamalira odwala. Zotsatira zabwino za chithandizo cha CAR-T zikuwonetsa kufunika kwa njira zatsopano komanso zapadera pochiza khansa zovuta, zomwe zimapatsa odwala mwayi wabwino ngati a C.

Musanayambe & masiku 28 pambuyo pake