Mr. C----Te Lymphoma Pūtau-B Nui e horapa ana (DLBCL)

Nō Īnia tēnei tūroro, a Mr. C, ā, e 55 ōna tau. I te tīmatanga o te tau 2019, i puta mai ia me te mate lymphadenopathy pūnaha pumau, ā, i rapu awhina hauora ia i tō mātou whare hauora. I whakahaerehia ngā aromatawai whānui, ā, i puta ai te mate ko te Diffuse Large B-Cell Lymphoma (DLBCL). I te mea he kaha te DLBCL, he mea nui te tīmatanga o te maimoatanga tonu hei whakatika i te mate.

I mua i te whiwhinga i te rongoā CAR-T, i haere a Mr. C ki te hōhipera hauora i waho o te hōhipera, tae atu ki ngā momo rongoā chemotherapy. I te tīmatanga, i whiwhi ia i te RCHOP hei rongoā tuatahi, ā, i muri mai ka whiwhi ia i ngā rongoā i muri mai, tae atu ki te REPOCH, R2-ICE, GEMOX-BTKi, Pola-BR, GB261, TQB2916, GA 101-Cedarbenamine-Doxil, ā, i te mutunga, ko te Inotuzumab. Ahakoa i tukuna ēnei rongoā mō tētahi wā roa, ā, i kitea he whai huatanga, kāore i taea te whakahaere i te mate, e whakaatu ana i te kaha o te DLBCL a Mr. C.

I te korenga o te urupare pai ki ngā maimoatanga tuku iho me te tere haere o tōna āhua, i tohua a Mr. C hei kaitono mō te maimoatanga pūtau CAR-T. Whai muri i ngā tikanga whakarite tino tika, i whiwhi a Mr. C i te maimoatanga pūtau CAR-T i te tīmatanga o te tau 2020. Ko tēnei huarahi maimoatanga auaha ko te whakarerekē i ngā pūtau-T o te tūroro kia whai hua ake ai te arotahi me te whakaeke i ngā pūtau matepukupuku.

E rua tekau mā waru ngā rā i muri i te whakaurunga anō o ngā pūtau CAR-T, i kitea te tino ngāwari o te mate, he tohu tēnei i te angitu o te maimoatanga. Nā tēnei hua i whakahou te tumanako me te hihiri ki a Mr. C me tana tīma hauora. Ko te urupare whakamiharo ki te rongoā CAR-T e whakaatu ana i te kaha o te rongoā ārai mate ki te rongoā i ngā mate pukupuku toto kaha pēnei i te DLBCL.

I ngā rā kei mua, ka haere tonu te tirotiro me te tirotiro i a Mr. C kia tata tonu ai tōna āhua. Ko te whakahaere i te mate mō te wā roa me te pumau he whāinga nui o tana mahere tiaki tonu. Ko te hua angitu o te rongoā CAR-T e whakaatu ana i te hiranga o ngā huarahi whaiaro me te auaha ki te whakahaere i ngā mate pukupuku uaua, e tuku ana i ngā tumanakohanga whai hua mō ngā tūroro pēnei i a Mr. C.

I mua me te 28 rā i muri mai