VaC----Diffuse Large B-cell Lymphoma (DLBCL)

Murwere uyu, VaC, anobva kuIndia uye ane makore makumi mashanu nemashanu ekuberekwa. Pakutanga kwa2019, akaonekwa aine chirwere che lymphadenopathy chinogara kwenguva refu uye akatsvaga rubatsiro rwechiremba kuchipatara chedu. Ongororo dzakakura dzakaitwa, zvikaita kuti aonekwe aine chirwere cheDiffuse Large B-Cell Lymphoma (DLBCL). Tichifunga nezvehunhu hweDLBCL hwakasimba, kutanga kurapwa nekukurumidza kwaive kwakakosha kuti chirwere ichi chigadziriswe zvinobudirira.

Vasati vatanga kurapwa neCAR-T, VaC vakambosangana nezviitiko zvakasiyana-siyana zvekurapa kunze kwechipatara zvine chekuita nekurapa kwakasiyana-siyana kwechemotherapy. Pakutanga, vakagamuchira RCHOP senzira yekutanga yekurapa, zvichiteverwa nekurapwa kwakatevera kunosanganisira REPOCH, R2-ICE, GEMOX-BTKi, Pola-BR, GB261, TQB2916, GA 101-Cedarbenamine-Doxil, uye pakupedzisira, Inotuzumab. Kunyange zvazvo kurapwa uku kwakaitwa kwenguva yakareba uye kwakaratidza kushanda zvakanaka, kwakakundikana kudzora zvirwere, zvichiratidza hunhu hwekurwisa hweDLBCL yaVaC.

Zvichitevera kusavapo kwemhinduro inogutsa kumishonga yechivanhu uye kufambira mberi nekukurumidza kwechirwere chavo, VaC vakaonekwa sevanhu vakakodzera kurapwa neCAR-T cell. Vachitevera nzira dzakanyatsogadzirirwa, VaC vakaitwa CAR-T cell therapy kutanga kwa2020. Iyi nzira itsva yekurapa inosanganisira kugadzirisa T cells dzemurwere kuti dzikwanise kurwisa nekurwisa masero egomarara zvinobudirira.

Mazuva makumi maviri nemasere mushure mekudzorerwa kwemasero eCAR-T, kupora kukuru kwechirwere kwakaonekwa, zvichiratidza kubudirira kwekurapwa. Izvi zvakaunza tariro itsva netariro kuna VaC nechikwata chavo chehutano. Mhinduro inoshamisa kuCAR-T therapy inoratidza mukana wekurapa nekudzivirira chirwere mukurapa kenza dzeropa dzakakomba dzakadai seDLBCL.

Zvichienderera mberi, VaC vachaenderera mberi nekuongororwa uye kugadzwa kwevanoda kurapwa kuti vanyatsoongorora mamiriro avo. Kudzora chirwere kwenguva refu uye kugadzikana ndizvo zvinangwa zvakakosha zvechirongwa chavo chekuchengeta varwere. Kubudirira kweCAR-T therapy kunosimbisa kukosha kwenzira dzakasiyana-siyana uye itsva mukurapa kenza dzakaoma, zvichipa mukana wekutarisira varwere vakaita saVaC.

Mazuva makumi maviri nemasere apfuura uye asati asvika