Te wikitoria i te Lymphoma Pūtau-B Nui marara me te Bioocus Dual CAR-T Therapy

Papamuri o te Tūroro

I kitea a Rodney, he tangata pakari nō tāwāhi, he Diffuse Large B-Cell Lymphoma (DLBCL), he momo lymphoma kore-Hodgkin e kaha ana te mate. I te 68 o ōna tau, i rapu ia i ngā huarahi maimoatanga matatau i muri i te korenga o ngā maimoatanga tuku iho. I tukuna ia ki tō mātou whare hoa mahi i te Tianjin Cancer Hospital, ā, i whakauru atu ia ki te kawa maimoatanga CAR-T takirua a Bioocus i raro i te nama maimoatanga P1549. Ka arotahi tēnei maimoatanga ki ngā antigens CD19 me CD20 i runga i ngā pūtau matepukupuku, me te tuku i tētahi whakaeke takirua hei whakarei ake i te whai huatanga me te whakaiti i te mōrearea o te hokinga mai.

Te Haerenga Maimoatanga

I tīmata te maimoatanga o Rodney i te marama o Hepetema 2025 me te werohanga o ngā pūtau CAR-T autologous i hangaia hei whakaatu i ngā kaiwhakawhiwhi antigen chimeric mō te CD19 me te CD20. Ko te tukanga i uru atu ki te kohikohi i tana tauira toto ā-taha (PB), te tukatuka hei hanga i ngā pūtau CAR-T whaiaro, me te werohanga i tētahi horopeta e rite ana ki ōna hiahia. I muri i te werohanga, i aro turukihia tōna ahunga whakamua mā roto i ngā whakamātautau toto raupapa i ngā rā aroturuki matua: Te Rā 4 (D4), Te Rā 7 (D7), me te Rā 10 (D10).

• D4 (12 o Hepetema, 2025):I te kitenga tuatahi i whakaatuhia he iti noa te kitea o ngā pūtau CAR-T, me ngā pūtau CD19+ CAR-T i te 0.50% o ngā pūtau CD3+ T (uara tino: 6.04 × 10^6/L) me ngā pūtau CD20+ CAR-T i te 0.41% (uara tino: 4.96 × 10^6/L). I tohu tēnei wāhanga wawe i te angitu o te whakaurunga.
• D7 (15 o Hepetema, 2025):I tere ake te horapa, me te pikinga o ngā pūtau CD19+ CAR-T ki te 1.68% (uara tino: 1.40 × 10^7/L) me ngā pūtau CD20+ CAR-T ki te 1.63% (uara tino: 1.36 × 10^7/L), e whakaatu ana i te kaha o te horapa.
• D10 (18 o Hepetema, 2025):I kitea te whānuitanga tino whakamiharo, me ngā pūtau CD19+ CAR-T i eke ki te 31.43% o ngā pūtau CD3+ T (uara tino: 3.13 × 10^8/L) me ngā pūtau CD20+ CAR-T i te 32.74% (uara tino: 3.26 × 10^8/L). I whakaatuhia e te tātaritanga huinga iti te tohatoha taurite puta noa i ngā pūtau CD4+ me CD8+ T, me te maha o ngā pūtau-T i te 2.9 × 10^9/L, tae atu ki te 34.35% o ngā pūtau CD3+ T.

I roto i te aroturukitanga, i whakaatuhia e te āhua ārai mate o Rodney ngā panonitanga pai, pērā i te pikinga o ngā pūtau-T paitini (CD3+CD8+ i te 69.56%), e whakaatu ana i te kaha o te rongoā ki te whakaoho i tana pūnaha ārai mate ki te lymphoma.

Ngā Hua Tino Pai

I te taenga ki te D10, ko te tipu tere o ngā pūtau CAR-T—neke atu i te 500 ngā wā ka piki ake te maha o ngā pūtau mai i te D4—i whakaatu i te kaha o te mahi ārai-pukupuku a te rongoā. Ko tēnei whānui tere he tohu mō te angitu o te maimoatanga CAR-T, he maha ngā wā e hono ana ki ngā murunga hōhonu me te roa i roto i ngā tūroro DLBCL. I pai te manawanui o Rodney ki te rongoā, kāore he raruraru nui i pūrongohia i te wāhanga aroturuki. Ko tana take he tauira mō te huarahi CAR-T takirua a Bioocus, kua tutuki ai te urupare katoa (CR) me ngā reiti urupare whānui (ORR) teitei puta noa i tā mātou rōpū tūroro o te ao.