Impendulo Ephawulekayo ku-Refractory Multiple Myeloma Ngemva Kokwelashwa Kwamaseli e-CAR-T

Iphrofayili YesiguliUMnu. Mohamed H., owesilisa oneminyaka engu-70 ubudala waseGibhithe

Ukuxilongwa KokuqalaI-myeloma eminingi ehileleke kakhulu emathanjeni. I-PET/CT yangaphambi kokwelashwa (Julayi 2024) ibonise izilonda zamathambo eziningi kakhulu kulo lonke uhlaka lwethambo lwe-axial kanye ne-appendicular, kanye nezilonda eziningi ezibhubhisayo kanye ne-SUV ephezulu engu-17.9, okubonisa isifo esisebenza kakhulu.

UkwelashwaNgemva kokuqhubeka nokwelashwa ngamakhemikhali avamile, uMnu. Mohamed wafuna izinketho ezithuthukisiwe wabe esekhetha i-Bioocus yokwelashwa ngamasosha omzimba aqondisiwe e-CAR-T cell.

Imiphumela Yokulandelela (Septhemba 2024 - kuphela ~ izinyanga ezimbili ngemuva kokwelashwa)I-PET/CT yomzimba wonke ephindaphindwayo iveziwe:

• Ukwehla okukhulu komsebenzi we-metabolic cishe kuzo zonke izilonda ezazisebenza ngaphambili
• Izilonda eziningi zixazululeke ngokuphelele (akukho ukuthathwa kwe-FDG okungavamile)
• I-SUV ephezulu yehle isuka ku-17.9 yaya ku-5.16
• Kusele kuphela ukumuncwa okuncane kwe-diffuse marrow, okuhambisana nezinguquko ezisabela ngemva kokwelashwa.
• Akukho foci entsha ye-hypermetabolic emathanjeni noma ezicutshini ezithambile

UMnu. Mohamed waba nezimpawu ngokuphelele ngemuva nje kokumnika. Ubika ukuthi usethole amandla, akasenabuhlungu emathanjeni, futhi usebuyele empilweni ejwayelekile yansuku zonke - imiphumela ayichaza ngokuthi “ithuba lesibili.”

"Ngaphambi kokuba ubuhlungu bube yonke indawo, futhi ngangicabanga ukuthi lokhu sekuwukuphela. Ngemva kokwelashwa kwe-CAR-T eBioocus, ngizizwa njengomuntu omusha. Iskeni yakamuva ikhombisa ukuthi umdlavuza usuphelile. Ngiyabonga kakhulu." — UMnu. Mohamed H.

Leli cala libonisa amandla amakhulu okwelashwa kwe-CAR-T ekufinyeleleni izimpendulo ezisheshayo nezijulile, ngisho nasezigulini esezikhulile ezine-multiple myeloma esezithuthukile, esezelashwe kakhulu.