I-Multiple Myeloma(MM)-02

Isiguli sase-Italy Sifuna Ukwelashwa Futhi Selashwa I-Multiple Myeloma Ngokwelashwa Kwe-CAR-T

UCinty, owesifazane oneminyaka engu-66 ubudala, watholakala ene-lambda light chain multiple myeloma, i-ISS stage I, e-Italy ngo-Okthoba 2018. Ngemva kokuthola imijikelezo emine ye-VTD regimen chemotherapy, waphuka engxenyeni yesithathu ye-clavicle kanye ne-peripheral neuropathy. Efuna ukwelashwa okuphumelelayo, wafakelwa amaseli amabili e-autologous stem ngo-Meyi 2019 nangoNovemba 2019, waphumelela ngokuphelele, futhi wagcinwa nge-lenalidomide yomlomo.

Kodwa-ke, ngo-Agasti 2020, ukuhlolwa okulandelayo kwe-PET/CT kwembula ukubhujiswa kwamathambo amasha kanye nokwanda okusheshayo kwamaketanga okukhanya angenawo ama-serum. I-Bone marrow biopsy yabonisa ukuqhubeka kwesifo, kanti ukuhlolwa kwe-FISH kwabonisa ukungalingani okusha kwe-cytogenetic: t(11;14). Ngemva kwemijikelezo emi-4 ye-DVD regimen chemotherapy eqala ngoSepthemba 2020, isifo sakhe asizange silawulwe futhi saqhubekela phambili. Naphezu kokushintshela emijikelezweni emi-3 ye-PCd regimen, ubuhlungu bakhe bamathambo baqhubeka futhi ukuvuvukala kwezitho zangaphansi kwamabili kwaba kubi kakhulu. Njengoba eseqede ukwelashwa okuningi okusebenzayo okwaziwayo emhlabeni wonke futhi wafakelwa amaseli amabili e-stem autologous, waba nokumelana nemithi eminingi.

Ngemva kokuzwa ngokusebenza kahle kwesilingo sezokwelapha se-CAR-T esikhungweni sethu se-CGT ngolwazi oluku-inthanethi, wafaka isicelo se-visa wafika eShayina ngoMashi 2021. Ngemva kwenyanga yokuvalelwa yedwa, wangeniswa esikhungweni sethu se-CGT ngo-Ephreli 22, 2021. Ngemva kochungechunge lokuhlolwa nokuhlolwa kwezifo, wathola ukumnika amaseli e-BCMA CAR-T ngemuva kokwelashwa ngamakhemikhali e-FC ngoMeyi walowo nyaka. Ngemva kokumnika, izimpawu zakhe zokuphila zazizinzile, futhi akazange athole imiphumela emibi ebalulekile ngaphandle komkhuhlane ophansi. Ukuvuvukala kwakhe kwezitho zombili kwancipha kancane kancane, futhi wajabula ukubona impilo yakhe iyonke ithuthuka.

Inyanga eyodwa ngemuva kokufakwa kwe-CAR-T, imiphumela yokuhlolwa kukaCinty ibonise: ukulinganiswa kwamaprotheni omchamo amahora angama-24 ku-50 mg/ngosuku, okuncishiswe kakhulu kusukela emazingeni okwamukelwa; izintambo zokukhanya ezingenayo i-serum: i-FLC-κ ku-4.58 mg/L kanye ne-FLC-λ ku-0.61 mg/L; kanti ukuhlolwa komnkantsha kwakubonisanga amangqamuzana abalulekile e-plasma. Wahlolwa ngokwezokwelapha njengosekukhululweni okuphelele (CR).

Njengamanje, ezinyangeni eziyisishiyagalombili ngemuva kokubuyela e-Italy, ubuhlungu bomhlane bukaCity kanye nokuvuvukala kwezitho zombili sekunyamalele ngokuphelele, futhi usenempilo enhle. Evela ezinkulungwaneni zamakhilomitha ukusuka lapha, iCity ibonge kakhulu isikhungo sethu se-CGT.

Lezi zimo ezimbili zezokwelapha ezivela ku-BIOOCUS Medical Group zibonisa ukuthi ngisho neziguli ezine-BCMA expression ephansi noma ezingenayo nhlobo ku-multiple myeloma zingaphumelela kahle ngokwelashwa ngamaseli e-BCMA CAR-T. Lokhu kubonisa intuthuko ekwelashweni kwe-CAR-T kwe-multiple myeloma, okuletha ithemba elisha ezigulini ezinezinkinga eziphambili zamaseli e-plasma kanye ne-multiple myeloma.