Ntau yam mob qog nqaij hlav (MM)-02

Tus Neeg Mob Italian Nrhiav Kev Kho Mob Thiab Kho Tau Mob Multiple Myeloma Nrog CAR-T Therapy

Cinty, ib tug poj niam muaj hnub nyoog 66 xyoo, tau kuaj pom tias muaj lambda light chain multiple myeloma, ISS theem I, hauv tebchaws Ltalis thaum Lub Kaum Hli 2018. Tom qab tau txais 4 lub voj voog ntawm VTD regimen chemotherapy, nws tau tsim ib qho pob txha tawg hauv sab thib peb ntawm clavicle thiab peripheral neuropathy. Nrhiav kev kho mob zoo dua, nws tau ua ob lub autologous stem cell transplants thaum Lub Tsib Hlis 2019 thiab Kaum Ib Hlis 2019, ua tiav kev zam txim tag nrho, thiab tau tswj hwm ntawm qhov ncauj lenalidomide.

Txawm li cas los xij, thaum Lub Yim Hli 2020, kev kuaj PET/CT tom qab tau qhia txog kev puas tsuaj ntawm cov pob txha tshiab thiab kev nce ntxiv sai ntawm cov saw hlau tsis muaj teeb meem hauv cov ntshav. Kev kuaj pob txha hauv cov pob txha qhia txog kev nce qib ntawm tus kab mob, thiab kev kuaj FISH tau qhia txog qhov tsis zoo ntawm cytogenetic tshiab: t(11;14). Tom qab 4 lub voj voog ntawm DVD regimen chemotherapy pib thaum Lub Cuaj Hli 2020, nws tus kab mob tsis tau tswj hwm thiab nce qib ntxiv. Txawm hais tias hloov mus rau 3 lub voj voog ntawm PCd regimen, nws qhov mob pob txha tseem muaj thiab ob sab ceg qis o tuaj zuj zus. Tom qab siv ntau txoj kev kho mob zoo thoob ntiaj teb thiab tau hloov ob lub hlwb autologous, nws tau tsim kev tiv thaiv rau ntau yam tshuaj.

Thaum nws kawm txog qhov ua tau zoo ntawm kev sim tshuaj CAR-T ntawm peb lub chaw CGT los ntawm cov ntaub ntawv online, nws tau thov daim visa thiab tuaj txog hauv Suav teb thaum Lub Peb Hlis 2021. Tom qab ib hlis ntawm kev cais tawm, nws tau raug xa mus rau peb lub chaw CGT thaum Lub Plaub Hlis 22, 2021. Tom qab ntau qhov kev kuaj mob thiab kev ntsuam xyuas kab mob, nws tau txais cov hlwb BCMA CAR-T tom qab FC chemotherapy preconditioning thaum Lub Tsib Hlis ntawm tib lub xyoo. Tom qab txhaj tshuaj, nws cov cim tseem ceeb tau ruaj khov, thiab nws tsis muaj kev phiv loj tsuas yog kub taub hau me ntsis xwb. Nws ob sab ceg qis o maj mam ploj mus, thiab nws zoo siab pom nws txoj kev noj qab haus huv zoo dua.

Ib hlis tom qab CAR-T infusion, Cinty cov txiaj ntsig kuaj pom tias: 24-teev cov protein hauv zis ntawm 50 mg/hnub, txo qis ntau ntawm cov qib nkag mus; serum free light chains: FLC-κ ntawm 4.58 mg/L thiab FLC-λ ntawm 0.61 mg/L; thiab kev ntsuam xyuas pob txha tsis pom muaj cov hlwb plasma tseem ceeb. Nws tau raug soj ntsuam hauv kev kho mob tias nws nyob hauv kev zam txim tag nrho (CR).

Tam sim no, yim lub hlis tom qab rov qab mus rau Ltalis, Cinty qhov mob nraub qaum thiab ob sab ceg qis oedema tau ploj mus tag, thiab nws muaj kev noj qab haus huv zoo. Los ntawm ntau txhiab mais deb, Cinty tau qhia nws qhov kev ris txiaj rau peb lub chaw CGT.

Ob qho kev kuaj mob no los ntawm BIOOCUS Medical Group qhia tau tias txawm tias cov neeg mob uas muaj BCMA qis lossis tsis muaj kev qhia tawm hauv ntau yam myeloma tuaj yeem ua tiav qhov ua tau zoo nrog BCMA CAR-T cell therapy. Qhov no sawv cev rau kev tawg ua ntu zus hauv kev kho mob CAR-T rau ntau yam myeloma, coj kev cia siab tshiab rau cov neeg mob uas muaj cov kab mob plasma cell thiab ntau yam myeloma.