I-Multiple Myeloma(MM)-02

Isigulana sase-Itali sifuna unyango kwaye sinyangekile kwi-Multiple Myeloma nge-CAR-T Therapy

UCinty, umfazi oneminyaka engama-66 ubudala, wafunyaniswa ene-lambda light chain multiple myeloma, i-ISS stage I, e-Itali ngo-Okthobha ka-2018. Emva kokufumana imijikelo emi-4 ye-VTD regimen chemotherapy, waphuka kwi-lateral third ye-clavicle kunye ne-peripheral neuropathy. Efuna unyango olusebenzayo ngakumbi, wenziwa utyando lwe-autologous stem cell kabini ngoMeyi ka-2019 nangoNovemba ka-2019, wafumana uxolelo olupheleleyo, kwaye wagcinwa etyaleni lenalidomide.

Nangona kunjalo, ngo-Agasti 2020, i-PET/CT scan elandelayo yabonisa ukutshatyalaliswa kwamathambo amatsha kunye nokwanda ngokukhawuleza kwe-serum free light chains. I-Bone marrow biopsy yabonisa ukuqhubela phambili kwesifo, kwaye uvavanyo lwe-FISH lwabonisa ukungaqheleki kwe-cytogenetic entsha: t(11;14). Emva kwemijikelo emi-4 ye-DVD regimen chemotherapy eqala ngoSeptemba 2020, isifo sakhe asizange silawulwe kwaye saqhubeka ngakumbi. Nangona etshintshela kwimijikelo emi-3 ye-PCd regimen, iintlungu zakhe zethambo zaqhubeka kwaye ukudumba kwamalungu asezantsi kwanda. Emva kokuphelelwa ziindlela ezininzi zonyango ezisebenza kwihlabathi liphela kwaye wafakelwa iiseli ze-stem ezimbini ze-autologous, waba nokumelana namayeza amaninzi.

Emva kokufunda ngokusebenza kakuhle kovavanyo lweklinikhi lwe-CAR-T kwiziko lethu le-CGT ngolwazi olukwi-intanethi, wafaka isicelo se-visa waza wafika eTshayina ngoMatshi 2021. Emva kwenyanga yokuvalelwa yedwa, wangeniswa kwiziko lethu le-CGT ngo-Epreli 22, 2021. Emva kothotho lweemvavanyo kunye novavanyo lwezifo, wafumana utyando lweeseli ze-BCMA CAR-T emva konyango lwe-FC chemotherapy ngoMeyi waloo nyaka. Emva kotyando, iimpawu zakhe ezibalulekileyo zazizinzile, kwaye akazange afumane miphumo mibi ibalulekileyo ngaphandle komkhuhlane ophantsi. Ukudumba kwakhe kwaphela kancinci kancinci, kwaye wavuya ukubona impilo yakhe iyonke iphucuka.

Emva kwenyanga emva kokufakwa kwe-CAR-T, iziphumo zovavanyo lukaCinty zibonise: ukulinganiswa kweprotheyini yomchamo iiyure ezingama-24 kwi-50 mg/ngosuku, okuncitshiswe kakhulu kumanqanaba okungeniswa; imixokelelwane yokukhanya engenalo i-serum: i-FLC-κ kwi-4.58 mg/L kunye ne-FLC-λ kwi-0.61 mg/L; kwaye uvavanyo lomongo wethambo alubonisanga ziseli zeplasma ezibalulekileyo. Uhlolwe ngokwezonyango njengokwi-complement remission (CR).

Okwangoku, emva kweenyanga ezisibhozo ebuyele e-Itali, iintlungu zomqolo zikaCity kunye nokudumba kwamalungu omabini asezantsi kuye kwaphela ngokupheleleyo, kwaye usempilweni entle. Ukusuka kumawaka eekhilomitha ukusuka apho, uCity uvakalise umbulelo wakhe onyanisekileyo kwiziko lethu le-CGT.

Ezi meko zimbini zonyango ezivela kwi-BIOOCUS Medical Group zibonisa ukuba kwanezigulane ezine-BCMA expression ephantsi okanye ezingenayo kwaphela kwi-multiple myeloma zinokuphumelela kakuhle ngonyango lweeseli ze-BCMA CAR-T. Oku kubonisa impumelelo kunyango lwe-CAR-T kwi-multiple myeloma, nto leyo ezisa ithemba elitsha kwizigulane ezineengxaki eziphambili zeeseli ze-plasma kunye ne-multiple myeloma.