Ọtụtụ Myeloma (MM)-02

Onye ọrịa Itali chọrọ ọgwụgwọ ma gwọọ ya site na ọgwụgwọ CAR-T.

A chọpụtara na Cinty, nwanyị dị afọ iri isii na isii, nwere ọrịa lambda light chain multiple myeloma, ISS stage I, na Itali n'ọnwa Ọktoba afọ 2018. Mgbe ọ natara usoro ọgwụgwọ VTD ugboro anọ, ọ gbawara n'akụkụ nke atọ nke clavicle na peripheral neuropathy. Ọ chọrọ ọgwụgwọ ka mma, e tinyere ya mkpụrụ ndụ stem abụọ na Mee 2019 na Nọvemba 2019, wee nweta mgbaghara zuru oke, e wee nye ya lenalidomide n'ọnụ.

Agbanyeghị, na Ọgọst 2020, nyocha PET/CT nke ọzọ gosiri mbibi ọkpụkpụ ọhụrụ na mmụba ngwa ngwa na agbụ ọkụ na-enweghị serum. Biopsy nke ụmị ọkpụkpụ gosiri ọganihu ọrịa ahụ, nnwale FISH gosikwara nsogbu cytogenetic ọhụrụ: t(11;14). Mgbe usoro ọgwụgwọ DVD regimen chemotherapy ugboro anọ malitere na Septemba 2020, ọrịa ya enweghị njikwa ma gaa n'ihu. N'agbanyeghị ịgbanwe gaa na usoro ọgwụgwọ PCd ugboro atọ, mgbu ọkpụkpụ ya nọgidere na-aka njọ, ọzịza ụkwụ ala abụọ ka njọ. Mgbe ọ gwụchara ọtụtụ ọgwụgwọ dị irè a ma ama n'ụwa niile ma mee mgbanwe mkpụrụ ndụ stem abụọ, ọ malitere iguzogide ọtụtụ ọgwụ.

Mgbe ọ nụrụ maka uru dị ukwuu nke nnwale ahụike CAR-T na ebe a na-agwọ ọrịa CGT anyị site na ozi ịntanetị, o tinyere akwụkwọ maka visa wee bịarute China na Machị 2021. Mgbe otu ọnwa nke ịnọpụ iche gasịrị, a nabatara ya na ebe a na-agwọ ọrịa CGT anyị na Eprel 22, 2021. Mgbe e mechara ọtụtụ nyocha na nyocha ọrịa, e tinyere mkpụrụ ndụ BCMA CAR-T mgbe e mechara ọgwụgwọ ọgwụ na FC na Mee nke otu afọ ahụ. Mgbe e tinyere ya ọgwụ ahụ, ihe ịrịba ama ya dị mkpa kwụsiri ike, ọ hụghịkwa mmetụta ọjọọ ọ bụla ma e wezụga ahụ ọkụ dị ala. Ọbara ya nke dị n'akụkụ abụọ belatara nwayọ nwayọ, obi dịkwa ya ụtọ ịhụ ka ahụike ya na-aka mma.

Otu ọnwa ka etinyere CAR-T n'ime mmamịrị, nsonaazụ ule Cinty gosiri: ọnụọgụ protein mmamịrị awa iri abụọ na anọ na 50 mg/ụbọchị, nke belatara nke ukwuu site na ọkwa nnabata; usoro ọkụ na-enweghị serum: FLC-κ na 4.58 mg/L na FLC-λ na 0.61 mg/L; na nyocha ụmị ọkpụkpụ egosighi mkpụrụ ndụ plasma dị mkpa. E lere ya anya n'ụlọọgwụ dịka onye nọ na mgbapụta zuru oke (CR).

Ugbu a, ọnwa asatọ ka ọ lọtara Itali, mgbu azụ na ọzịza nke aka na ụkwụ Cinty apụọla kpamkpam, ahụ dịkwa ya mma. Site na ọtụtụ puku kilomita site n'ebe ahụ, Cinty gosipụtara ekele ya nye ebe anyị na-ahụ maka ọgwụgwọ ọrịa kansa (CGT).

Ihe abụọ a sitere na BIOOCUS Medical Group na-egosi na ọbụna ndị ọrịa nwere obere ma ọ bụ enweghị ngosipụta BCMA na ọtụtụ myeloma nwere ike nweta ezigbo irè site na ọgwụgwọ mkpụrụ ndụ BCMA CAR-T. Nke a na-anọchite anya ọganihu na ọgwụgwọ CAR-T maka ọtụtụ myeloma, na-eweta olileanya ọhụrụ nye ndị ọrịa nwere nsogbu mkpụrụ ndụ plasma dị elu na ọtụtụ myeloma.