Te Myeloma Maha (MM)-02

E rapu ana tētahi tūroro Itari i te maimoatanga, ā, kua ora ia i te Multiple Myeloma mā te CAR-T Therapy.

I kitea a Cinty, he wahine 66-tau te pakeke, he myeloma maha lambda light chain, te wāhanga ISS I, i Itari i te marama o Oketopa 2018. Whai muri i te whiwhinga o ngā huringa e 4 o te rongoā chemotherapy VTD, ka puta he whati i te taha tuatoru o te clavicle me te neuropathy peripheral. I te rapu maimoatanga whai hua ake, e rua ngā whakawhitinga pūtau take autologous i a ia i te marama o Mei 2019 me Noema 2019, ā, ka mutu te whakaora katoa, ā, i mau tonu ia ki te lenalidomide ā-waha.

Heoi, i te marama o Ākuhata 2020, i whakaatuhia e te matawai PET/CT whai muri te whakangaromanga wheua hou me te pikinga tere o ngā mekameka mārama kore-toto toto. I tohuhia e te koiora wheua wheua te whanaketanga o te mate, ā, i whakaatuhia e te whakamātautau FISH he rerekētanga cytogenetic hou: t(11;14). Whai muri i ngā huringa e 4 o te rongoā DVD chemotherapy i tīmata i te marama o Hepetema 2020, kāore i taea te whakahaere i tana mate, ā, ka piki haere tonu. Ahakoa te huri ki te 3 huringa o te rongoā PCd, ka mau tonu te mamae o tana wheua, ā, ka kino haere te pupuhi o ngā waewae o raro e rua. I te mea kua pau katoa i a ia te maha o ngā maimoatanga whai hua e mohiotia ana i te ao, ā, kua rua ngā whakawhitinga pūtau take autologous i tukuna ki a ia, ka whanake ia he ātete ki ngā rongoā maha.

I tōna rongonga i te whai huatanga nui o te whakamātautau haumanu CAR-T i tō mātou pokapū CGT mā roto i ngā mōhiohio ipurangi, ka tono ia mō tētahi visa, ā, ka tae ki Haina i te marama o Poutū-te-rangi 2021. Whai muri i te marama kotahi o te karantini, ka whakaurua ia ki tō mātou pokapū CGT i te 22 o Paenga-whāwhā, 2021. Whai muri i te raupapa o ngā whakamātautau me ngā aromatawai mate, ka whiwhi ia i te werohanga o ngā pūtau BCMA CAR-T i muri i te whakangungu mua o te rongoā FC i te marama o Mei o taua tau anō. Whai muri i te werohanga, i pumau ana tohu ora, ā, kāore i pāngia e ia ngā pānga taha nui engari ko te kirika iti. I āta heke haere te pupuhi o ōna waewae o raro, ā, i harikoa ia ki te kite i te pai haere o tōna hauora whānui.

Kotahi marama i muri i te werohanga CAR-T, i whakaatuhia e ngā hua whakamātautau a Cinty: te ine i te pūmua mimi 24-hāora i te 50 mg/rā, he iti iho i ngā taumata whakaurunga; ngā mekameka mārama kore toto: FLC-κ i te 4.58 mg/L me te FLC-λ i te 0.61 mg/L; ā, i whakaatuhia e te aromatawai hinu wheua kāore he pūtau plasma nui. I aromatawaihia ia i roto i te haumanu kua tino murua ia (CR).

I tēnei wā, e waru marama i muri i tana hokinga mai ki Itari, kua ngaro katoa te mamae o te tuara me te pupuhi o ngā waewae o raro o Cinty, ā, kei te ora pai ia. Mai i ngā mano maero te tawhiti, i whakapuaki a Cinty i tana mihi nui ki tā mātou pokapū CGT.

E whakaatu ana ēnei kēhi haumanu e rua mai i te Rōpū Hauora BIOOCUS ahakoa he iti, he kore rānei te whakaaturanga BCMA i roto i te myeloma maha, ka taea e rātou te whakatutuki i te whai huatanga pai me te rongoā pūtau BCMA CAR-T. He putanga hou tēnei i roto i te maimoatanga CAR-T mō te myeloma maha, e kawe mai ana i te tumanako hou ki ngā tūroro he mate pūtau plasma matatau me te myeloma maha.