Myeloma Maha me te Plasmacytoma Extramedullary

Koinei te take o tētahi tūroro tāne 73-tau te pakeke i kitea he myeloma maha, he uaua ake nā te noho mai o te plasmacytoma extramedullary. I te roanga o te maimoatanga ki a Dara-VRD (Daratumumab, Bortezomib, Lenalidomide, Dexamethasone), i mau tonu te plasmacytoma extramedullary, ā, ka nui te mamae me te kore whakamarie o te tūroro.

I te whakaaro ki te āhua kaha o te mate me te kore urupare ki ngā maimoatanga tuku iho, i whakaurua te tūroro ki tētahi whakamātautau haumanu mō te rongoā pūtau BCMA CAR-T. I muri i te whai i ngā mahi whakarite e tika ana, tae atu ki te lymphodepletion, i whiwhi te tūroro i te werohanga o ngā pūtau BCMA CAR-T.

He mea whakamiharo, i roto i ngā rā 10 i muri i te werohanga, i pāngia te tūroro e te urupare cytokine release syndrome (CRS) tuarua-tohu, e tohu ana i te kaha o te whakahohenga ārai mate. I tua atu, i kitea he CRS ā-rohe nui i te wāhi o te plasmacytoma extramedullary.

Ko te mea whakamiharo rawa atu, i roto i tēnei wā poto, kua ngaro katoa te whara extramedullary i ātete ki te rongoā i mua, i kitea nei he ātete ki ngā momo chemotherapy maha, ngā kaihoko kua tohua, me ngā paturopi monoclonal. I tutuki i te tūroro te murunga katoa, e tohu ana i te angitu o te maimoatanga.

I roto i te tukanga maimoatanga katoa, i tirotirohia tata te tūroro e te tīma hauora mō ngā tohu o ngā pānga kino, ā, i whakaratohia he manaaki tautoko whānui. I uru atu ki tēnei te whakahaere i ngā tohumate CRS me te aro atu ki ētahi atu raruraru e pā ana ki te maimoatanga.

I te haere tonu o te maimoatanga, i aro turuki tonu te tīma hauora i te urupare a te tūroro ki te rongoā pūtau BCMA CAR-T. I whakahaerehia ngā aromatawai auau hei aromatawai i te whai huatanga o te maimoatanga, me te aro wawe atu ki ngā pānga taha e puta ake ana.

Whai muri i te whakatutukitanga whakamiharo o te murunga katoa, i tino pai ake te kounga o te oranga o te tūroro, me te whakamamae i te mamae me te kore whakamarie e pā ana ki te plasmacytoma extramedullary. I te mea kua whakahaeretia te mate, ka taea e te tūroro te hoki anō ki ngā mahi o ia rā, me te pai ake o te oranga whānui.

Heoi anō, i te mōhio ki te hiranga o te tiaki whai muri mō te wā roa, i noho kaha tonu tā mātou tīma hauora ki te whai wāhi atu ki te haerenga whai muri i te maimoatanga a te tūroro. I whakaritea he wā tirotiro whai muri auau hei aroturuki i te āhua o te tūroro, hei aromatawai i te roa o te urupare ki te maimoatanga, me te aro atu ki ngā pānga taha ka hoki anō pea, ka puta wawe rānei.

Haunga te aroturuki hauora, i whakaratohia e tā mātou whare hauora he ratonga tautoko whānui hei āwhina i te tūroro ki te urutau ki te oranga i muri i te maimoatanga. I uru atu ki tēnei te urunga atu ki ngā ratonga tohutohu, ngā kaupapa whakaora, me ngā rauemi mātauranga hei āwhina i te tūroro me tōna whānau ki te whakatere i te oranga me te pupuri i te oranga hauora.

Ko te putanga angitu o tēnei take ehara i te mea e whakaatu ana i te whai huatanga o te rongoā pūtau BCMA CAR-T ki te rongoā i te myeloma maha uaua, engari e whakaatu ana hoki i te hiranga o te tiaki whaiaro me te tiaki maha-mātauranga ki te whakahaere i ngā mate pukupuku toto uaua. Ko tā mātou whakapau kaha ki te whakarato tautoko tonu me te tiaki whai muri e whakaata ana i tō mātou whakapau kaha ki te whakarite i ngā putanga pai rawa atu mō ā mātou tūroro i tua atu i te wāhanga maimoatanga.

I mua me te 3 marama i muri i te werohanga