Lupus Erythematosus Pūnaha (SLE)-03

I te marama o Ākuhata 2016, i puta mai he whero iti ki a Whaea A, 20 tau te pakeke, puta noa i tōna tinana, ā, he maha ngā kirika, ā, he iti te maha o ngā pereti toto i roto i a ia, e whitu marama i muri i tana whānautanga. Whai muri i ngā whakamātautau maha i ngā hōhipera o te rohe, i kitea he mate lupus erythematosus (SLE) tōna i tētahi hōhipera ā-rohe. I te marama o Oketopa o taua tau anō, ka tīmata ia ki te whiwhi maimoatanga i tana hōhipera o te rohe.

"Mō ngā tau e whitu kua pahure ake nei, kua haere ahau ki te hōhipera i ia marama mō ngā rongoā, ngā whakamātautau toto auau, ngā whakamātautau mimi, me ngā rongoā me ngā werohanga tonu, engari i haere tonu te mate, he tino mamae," te kī a Whaea A. I roto i te ngana ki te rongoā i tōna mate, i haria ia e tana tāne ki ētahi hōhipera, engari nā te nui o ngā utu kāore i whakaora i tōna āhua. I te mutunga, ka pāngia ia e te lupus nephritis me te encephalopathy, ā, i te marama o Hepetema 2022, ka pokangahia tōna roro. I te rongonga ka taea e te rongoā CAR-T te rongoā i te SLE, ka rapu āwhina a Whaea A i tō mātou hōhipera, ā, i reira ka tātarihia tonutia e te tīma tohunga tōna āhua.

I whakamārama te tākuta, "I te wā i whakaurua tuatahitia ai tēnei tūroro ki te whare hauora, he nui te pūmua i roto i te mimi, ā, he pai ngā paturopi. Kua whai wāhi ia ki ngā rongoā tuku iho mō ngā homoni me ngā rongoā ārai mate, tae atu ki ngā rongoā koiora e whitu, engari kāore i whai hua. I pāngia ia e te lupus encephalopathy, te toto toto tiketike o te pūkahukahu, te fibrosis pūkahukahu, ā, i tohuhia e tana koiora whatukuhu he lupus hohe. I whakaatuhia e tēnei kāore i whai hua ngā rongoā tuku iho me ngā rongoā koiora." Ki te whakatauritea ki ngā matū tuku iho, ki ngā paturopi monoclonal rānei, ka taea e ngā pūtau CAR-T te uru ki ngā arai kiko, te horapa whānui i roto i ngā kiko, me te whakaputa i te pānga cytotoxic, inā koa ki ngā pūtau B, ki ngā pūtau plasma rānei i roto i ngā āputa kiko kāore e taea e ngā paturopi monoclonal te toro atu. Ki te kore he 'purapura o te mate,' ka heke haere ngā paturopi aunoa o te tūroro, ka hoki ngā tāpiringa ki te noho noa, ā, ka ngawari te whakamamae, ka ngaro rānei ngā tohu." Nō reira, i angitu te whai i te rongoā CAR-T a te tūroro.

I mea atu a Whaea A, "Kua ngaro ngā ira whero o tōku tinana ināianei, ā, kāore au e hiahia ana ki ngā rongoā homoni, ki ngā rongoā ārai mate rānei. I mua he maha ngā whakamātautau toto me te mimi i mahia e au, engari ināianei ka hiahiatia e au i ia ono marama. He pai tōku āhua whānui, ā, he noa ngā tohu katoa. Ko te rā nei taku haerenga tuatoru ki te tirotiro i muri mai, ā, he pai ngā hua o ngā haerenga e rua kua pahure ake nei. E tino mihi ana ahau ki ngā kaimahi hauora mō te homai i tētahi whai wāhitanga tuarua ki te ora."