Tsarin Lupus Erythematosus (SLE)-03

A watan Agusta na shekarar 2016, Ms. A mai shekaru 20 ta sami ƙananan tabo ja a jikinta da kuma yawan zazzaɓi, kuma tana da ƙarancin ƙwayoyin platelet, watanni bakwai bayan haihuwa. Bayan gwaje-gwaje da yawa a asibitocin yankin, an gano tana da cutar lupus erythematosus (SLE) a wani asibiti na lardi. A watan Oktoba na wannan shekarar, ta fara samun magani a asibitin da ke yankinta.

"Shekaru bakwai da suka gabata, nakan ziyarci asibiti duk wata don neman magani, gwajin jini akai-akai, gwajin fitsari, da kuma magunguna da allurai akai-akai, amma yanayin ya ci gaba da sake dawowa, wanda hakan ya yi mata zafi sosai," in ji Ms. A ƙoƙarinta na magance cutarta, mijinta ya kai ta asibitoci da dama, amma tsadar da aka yi mata ba ta kawo mata sauƙi ba. Daga ƙarshe, ta kamu da cutar lupus nephritis da encephalopathy, kuma a watan Satumba na 2022, an yi mata tiyatar kwakwalwa. Jin cewa maganin CAR-T zai iya magance cutar SLE, Ms. A ta nemi taimako daga asibitinmu, inda ƙungiyar ƙwararru ta yi nazari kan yanayinta nan da nan.

Likitan ya bayyana cewa, "Lokacin da aka fara kwantar da wannan majiyyaci, tana da kumburin fata, furotin mai yawa, da kuma ƙwayoyin rigakafi masu kyau. An yi mata maganin hormones na gargajiya da na immunosuppressive, da kuma zagaye bakwai na maganin halittu, amma babu wanda ya yi tasiri. Ta kamu da cutar lupus encephalopathy, hauhawar jini na huhu, fibrosis na huhu, kuma biopsy ɗinta na koda ya nuna cewa lupus mai aiki ne. Wannan ya nuna cewa magungunan gargajiya da na halitta ba su da tasiri." Idan aka kwatanta da magungunan sinadarai na gargajiya ko magungunan monoclonal, ƙwayoyin CAR-T na iya shiga shingen nama, su bazu ko'ina a cikin kyallen takarda, kuma su yi tasirin cytotoxic, musamman a kan ƙwayoyin B ko ƙwayoyin plasma a cikin gibin nama da ƙwayoyin rigakafi na monoclonal ba za su iya isa ba. Ba tare da 'tsaba na cuta ba,' ƙwayoyin rigakafi na marasa lafiya suna raguwa a hankali, suna komawa zuwa al'ada, kuma alamun suna raguwa ko ɓacewa a hankali." Saboda haka, majiyyacin ya yi nasarar yin maganin CAR-T.

Ms. A ta ce, "Yanzu jajayen tabo a jikina sun ɓace, kuma ba na buƙatar magungunan hormones ko immunosuppressants. A da ina yin gwajin jini da fitsari akai-akai, amma yanzu ina buƙatar su ne kawai bayan wata shida. Jikina gaba ɗaya yana da kyau, kuma duk alamu sun yi daidai. Yau ita ce ziyara ta ta uku da na bi, kuma sakamakon ziyara biyu da suka gabata sun yi kyau. Ina matukar godiya ga ma'aikatan lafiya da suka ba ni dama ta biyu ta rayuwa."