Tsarin Lupus Erythematosus (SLE)-01

Xiaohuan mai shekaru 24 tana karatun likitanci a wata jami'a tsawon shekaru uku kuma tana fama da cutar lupus erythematosus (SLE) kusan shekaru 10. "An gano ni ina da shekaru 10, kuma likitan ya ce yana da matukar wahala a warke, cewa zan iya sarrafa shi da magani kawai," in ji Xiaohuan da murmushi mai ɗaci. A cikin shekaru goma da suka gabata, dole ne ta je duba lafiyarta na wata-wata da kuma rubuta mata magani, kuma ta yi maganin hormones, maganin rage radadi, da kuma maganin halittu, amma babu wanda ya yi tasiri. Ta sha fama da matsanancin asarar gashi, kuraje da yawa, zazzabi mai yawan dawowa, da kuma ciwo mai yawa.

Bayan gwaje-gwaje daban-daban na farko, Xiaohuan ta cika dukkan sharuɗɗan asibiti na maganin CAR-T don SLE. Wata ƙungiyar ƙwararru ta tsara tsarin magani bisa ga yanayinta kuma ta shirya sosai don tsarin tattara ƙwayoyin halitta. A ranar 28 ga Maris, an fara tattara ƙwayoyin mononuclear. A ranar 22 ga Afrilu, ta fara yin maganin chemotherapy na lymphodepletion. A ranar 28 ga Afrilu, an sake saka ƙwayoyin. An saka ƙwayoyin T miliyan ashirin da aka gyara a cikin jijiyar Xiaohuan a hankali, suna kai hari kai tsaye ga ƙwayoyin lupus B, suna fara yaƙin "kai hari daidai, karya su ɗaya bayan ɗaya".

A ranar 4 ga Yuni, kwanaki 38 bayan allurar, Xiaohuan ya koma asibiti don ci gaba da duba lafiyarsa. Sakamakon gwajin ya nuna cewa dukkan alamu masu mahimmanci sun ragu zuwa matsakaicin da aka saba. "Ba na buƙatar magungunan hormone; yana jin kamar rayuwa ta fara ne kawai," in ji Xiaohuan cikin farin ciki.