I-Systemic Lupus Erythematosus (SLE)-01

UXiaohuan oneminyaka engama-24 ubudala ebefunda ubugqirha eyunivesithi kangangeminyaka emithathu kwaye ebenesifo se-systemic lupus erythematosus (SLE) phantse iminyaka eli-10. "Ndafunyaniswa ndineminyaka eli-10 ubudala, kwaye ugqirha wathi kunzima kakhulu ukunyanga, ukuba ndingayilawula kuphela ngamayeza," utshilo uXiaohuan encumile kabuhlungu. Kwiminyaka elishumi edlulileyo, kwafuneka aye kuhlolwa rhoqo ngenyanga kunye nemithi emiselweyo, kwaye wafumana unyango lweehomoni, unyango lokunciphisa umzimba, kunye nonyango lwebhayoloji, kodwa akukho nanye eyasebenzayo. Unyamezele ukulahleka kweenwele okukhulu, ukurhawuzelela okuninzi, umkhuhlane ophezulu ophindaphindiweyo, kunye nentlungu ebanzi.

Emva kovavanyo lokuqala olwahlukeneyo, uXiaohuan wahlangabezana nazo zonke iikhrayitheriya zonyango lwe-CAR-T lwe-SLE. Iqela leengcali layila ngononophelo isicwangciso sonyango esisekelwe kwimeko yakhe kwaye lalungiselela ngononophelo inkqubo yokuqokelelwa kweeseli. Ngomhla wama-28 kuMatshi, kwaqala ukuqokelelwa kweeseli ze-mononuclear. Ngomhla wama-22 ku-Epreli, waqala i-lymphodepleting chemotherapy. Ngomhla wama-28 ku-Epreli, iiseli zaphinda zafakwa. Iiseli ze-T eziguqulweyo ze-CAR ezingamashumi amabini ezigidi zafakwa kancinci kancinci emthanjeni kaXiaohuan, zijolise ngqo kwiiseli ze-lupus B, ziqala ukulwa "ngokuchanekileyo, ziwaphule nganye nganye".

Ngomhla wesi-4 kweyeSilimela, emva kweentsuku ezingama-38 emva kokumnika, uXiaohuan wabuyela esibhedlele ukuze ahlolwe. Iziphumo zovavanyo zibonise ukuba zonke izalathisi ezibalulekileyo zehle zaya kumanqanaba aqhelekileyo. "Andisawadingi amayeza eehomoni; ndivakalelwa kukuba ubomi buqala nje," utshilo uXiaohuan ngovuyo.