Systemic Lupus Erythematosus (SLE)-01

Xiaohuan wazaka 24 wakhala akuphunzira zamankhwala ku yunivesite kwa zaka zitatu ndipo wakhala akudwala matenda a systemic lupus erythematosus (SLE) kwa zaka pafupifupi 10. "Ndinapezeka ndili ndi zaka 10, ndipo dokotala anati zinali zovuta kwambiri kuchiritsa, kuti ndingathe kuziletsa ndi mankhwala okha," adatero Xiaohuan akumwetulira mokwiya. M'zaka khumi zapitazi, adayenera kupita kukayezetsa mwezi uliwonse ndi kumwa mankhwala, ndipo adapatsidwa chithandizo cha mahomoni, chithandizo choletsa chitetezo chamthupi, komanso chithandizo chamankhwala chachilengedwe, koma palibe chomwe chidagwira ntchito. Anavutika ndi kutaya tsitsi kwambiri, ziphuphu zambiri, malungo akuluakulu, komanso ululu waukulu.

Pambuyo pa mayeso oyambirira osiyanasiyana, Xiaohuan anakwaniritsa zofunikira zonse zachipatala za chithandizo cha CAR-T cha SLE. Gulu la akatswiri linapanga mosamala dongosolo la chithandizo kutengera momwe alili ndipo linakonzekera mosamala njira yosonkhanitsira maselo. Pa Marichi 28, kusonkhanitsa maselo a mononuclear kunayamba. Pa Epulo 22, anayamba chemotherapy yochotsa ma lymphodepleting. Pa Epulo 28, maselowo anabwezeretsedwanso. Maselo a T osinthidwa a CAR miliyoni makumi awiri analowetsedwa pang'onopang'ono mumtsempha wa Xiaohuan, akulunjika mwachindunji maselo a lupus B, kuyambitsa nkhondo "yolondola, kuwaswa mmodzi ndi mmodzi".

Pa June 4, tsiku la 38 pambuyo pa kumwa mankhwala oletsa kutupa, Xiaohuan anabwerera kuchipatala kuti akalandire chithandizo. Zotsatira za mayeso zinasonyeza kuti zizindikiro zonse zofunika kwambiri zatsika kufika pamlingo wabwinobwino. "Sindikufunanso mankhwala a mahomoni; ndikumva ngati moyo ukungoyamba kumene," anatero Xiaohuan mosangalala.