I-Systemic Lupus Erythematosus (SLE)-01

UXiaohuan oneminyaka engu-24 ubudala ubelokhu efunda ubudokotela eyunivesithi iminyaka emithathu futhi ubelokhu ehlushwa yi-systemic lupus erythematosus (SLE) iminyaka ecishe ibe yi-10. "Ngatholakala ngineminyaka eyi-10, kanti udokotela wathi kunzima kakhulu ukuyelapha, ukuthi ngingayilawula kuphela ngemithi," kusho uXiaohuan emomotheka kabuhlungu. Eminyakeni eyishumi edlule, kwadingeka aye kohlolwa njalo ngenyanga kanye nemithi kadokotela, futhi welashwa ngama-hormone, ukwelashwa ngokucindezela amasosha omzimba, kanye nokwelashwa ngebhayoloji, kodwa akukho okwaphumelela. Wabekezelela ukulahlekelwa izinwele okukhulu, ukuqubuka okuningi, umkhuhlane ophindaphindayo, kanye nobuhlungu obusakazekile.

Ngemva kokuhlolwa kokuqala okuhlukahlukene, uXiaohuan wahlangabezana nazo zonke izindlela zokwelapha ze-CAR-T therapy ye-SLE. Ithimba lochwepheshe laklama ngokucophelela uhlelo lokwelashwa olusekelwe esimweni sakhe futhi lalungiselela ngokucophelela inqubo yokuqoqwa kwamaseli. NgoMashi 28, kwaqala ukuqoqwa kwamaseli e-mononuclear. Ngo-Ephreli 22, waqala ukwelashwa ngamakhemikhali okususa amaseli emzimbeni. Ngo-Ephreli 28, amaseli aphinde afakwa. Amaseli e-T aguquliwe e-CAR ayizigidi ezingamashumi amabili afakwa kancane kancane emthanjeni kaXiaohuan, eqondisa ngqo amaseli e-lupus B, eqala ukulwa "okuqondile, ukuwaphula ngamunye ngamunye".

Ngomhlaka-4 kuJuni, usuku lwama-38 ngemuva kokumuncwa, uXiaohuan wabuyela esibhedlela ukuze ahlolwe. Imiphumela yokuhlolwa ibonise ukuthi zonke izinkomba ezibalulekile zase zehle zaya ezingeni elijwayelekile. "Angisadingi imithi yama-hormone; kuzwakala sengathi impilo isanda kuqala," kusho uXiaohuan ngenjabulo.