Systemic Lupus Erythematosus (SLE)-01

Xiaohuan ane makore makumi maviri nemana ekuberekwa anga achidzidza zvekurapa payunivhesiti kwemakore matatu uye anga achirwara nechirwere chesystemic lupus erythematosus (SLE) kwemakore anoda kusvika gumi. "Ndakaonekwa kuti ndine chirwere ichi pazera remakore gumi, uye chiremba akati chaive chakaoma kurapa, kuti ndaigona kungochidzora nemishonga chete," akadaro Xiaohuan achinyemwerera nehasha. Mumakore gumi apfuura, aifanira kuenda kunoongororwa mwedzi wega wega uye kunopihwa mishonga, uye akarapwa nehomoni, immunosuppressive therapy, uye biological therapy, asi hapana chakashanda. Akatsungirira kurasikirwa nebvudzi zvakanyanya, mapundu akawanda, fivha yakakwira inoramba ichiitika, uye kurwadziwa kwakapararira.

Mushure mekuongororwa kwekutanga kwakasiyana-siyana, Xiaohuan akazadzisa zvese zvinodiwa pakurapa kweCAR-T yeSLE. Chikwata chenyanzvi chakagadzira hurongwa hwekurapa hwakavakirwa pamamiriro ake ezvinhu uye chakagadzirira nekungwarira maitiro ekuunganidza masero. Musi wa28 Kurume, kuunganidzwa kwemasero emononuclear kwakatanga. Musi wa22 Kubvumbi, akatanga chemotherapy yekubvisa lymphodepleting. Musi wa28 Kubvumbi, masero aya akaiswazve. Mamiriyoni makumi maviri emasero eT akagadziriswa neCAR akaiswa zvishoma nezvishoma mutsinga yaXiaohuan, achinanga zvakananga masero elupus B, achitanga kurwa "kwakanyatsojeka, kuaputsa rimwe nerimwe".

Musi wa4 Chikumi, zuva rechi38 mushure mekupinzwa mushonga, Xiaohuan akadzokera kuchipatara kuti anoongororwa. Zvakabuda muongororo zvakaratidza kuti zviratidzo zvese zvakakosha zvakanga zvadzikira kusvika padanho rakajairika. "Handichadi mishonga yemahormone; zvinoita sekunge hupenyu hwava kutanga," Xiaohuan akadaro achifara.