Systemic Lupus Erythematosus (SLE)-03

Muna Nyamavhuvhu 2016, Ms. A ane makore makumi maviri ekuberekwa akatanga kuva nemavanga matsvuku mumuviri wake wese uye aigara achirwara nefivha, uye akanga asina maplatelet akawanda, mwedzi minomwe mushure mekusununguka. Mushure mekuongororwa kakawanda muzvipatara zvemuno, akaonekwa aine chirwere chesystemic lupus erythematosus (SLE) kuchipatara cheprovince. Muna Gumiguru wegore rimwe chete, akatanga kurapwa kuchipatara chemuno.

"Kwemakore manomwe apfuura, ndaifanira kushanyira chipatara mwedzi wega wega kuti ndipiwe mishonga, kuongororwa ropa kakawanda, kuongororwa weti, uye mishonga nejekiseni nguva dzose, asi chirwere ichi chakaramba chichidzoka, izvo zvairwadza zvikuru," akadaro Ms. A. Mukuedza kurapa chirwere chavo, murume wavo akamuendesa kuzvipatara zvakawanda, asi mitengo yakakwira haina kuunza zororo kuchirwere chavo. Pakupedzisira, vakatanga chirwere che lupus nephritis ne encephalopathy, uye muna Gunyana 2022, vakavhiyiwa uropi. Vachinzwa kuti kurapa kweCAR-T kunogona kurapa SLE, Ms. A vakatsvaga rubatsiro kubva kuchipatara chedu, uko timu yenyanzvi yakabva yaongorora mamiriro avo.

Chiremba akatsanangura kuti, "Murwere uyu paakatanga kubvumidzwa, aive nekuzvimba kwakapararira, proteinuria yakawanda, uye ma antibodies akanaka. Akanga amborapwa nemahormone echinyakare uye immunosuppressive therapy, pamwe nekurapwa nemuviri kanomwe, asi hapana chakashanda. Akava ne lupus encephalopathy, pulmonary hypertension, pulmonary fibrosis, uye biopsy yake yeitsvo yakaratidza kuti ane lupus inoshanda. Izvi zvakaratidza kuti kurapwa kwechinyakare uye kwemuviri kwakanga kusingabatsiri." Zvichienzaniswa nemakemikari echinyakare kana ma monoclonal antibodies, masero eCAR-T anogona kupinda muzvivharo zvenyama, kupararira zvakanyanya munyama, uye kuita cytotoxic effect, kunyanya kurwisa masero eB kana masero eplasma mumipata yenyama isingasvikwe ne monoclonal antibodies. Pasina 'mbeu dzechirwere,' ma autoantibodies emurwere anodzikira zvishoma nezvishoma, ma complements anodzokera kune zvakajairika, uye zviratidzo zvinopera zvishoma nezvishoma." Nokudaro, murwere akabudirira kurapwa neCAR-T.

Mai A vakati, "Iye zvino mavanga matsvuku pamuviri wangu apera, uye handichadi mishonga yemahormone kana mishonga inodzvinyirira immune system. Ndaimboongororwa ropa neweti kakawanda, asi ikozvino ndinongoda chete mwedzi mitanhatu yega yega. Mamiriro angu ese akanaka, uye zviratidzo zvese zvakanaka. Nhasi inguva yangu yechitatu yekushanya, uye mhedzisiro yekushanya kaviri kwapfuura yaive yakanaka. Ndinotenda zvikuru vashandi vekurapa nekundipa mukana wechipiri muhupenyu."