I-Systemic Lupus Erythematosus (SLE)-03

Ngo-Agasti 2016, uNksz A oneminyaka engu-20 ubudala waba namabala abomvu amancane emzimbeni wakhe wonke kanye nomkhuhlane ovamile, futhi waba nama-platelet aphansi, ezinyangeni eziyisikhombisa ngemuva kokubeletha. Ngemva kokuhlolwa kaningi ezibhedlela zasendaweni, kwatholakala ukuthi une-systemic lupus erythematosus (SLE) esibhedlela sesifundazwe. Ngo-Okthoba walowo nyaka ofanayo, waqala ukwelashwa esibhedlela sendawo.

"Eminyakeni eyisikhombisa edlule, bekufanele ngivakashele isibhedlela njalo ngenyanga ukuze ngithole imithi kadokotela, ukuhlolwa kwegazi njalo, ukuhlolwa komchamo, kanye nemithi eqhubekayo kanye nokujova, kodwa lesi simo sasilokhu siphindaphindeka, okwakubuhlungu kakhulu," kusho uNkk. A. Ezama ukwelapha lesi sifo sakhe, umyeni wakhe wamyisa ezibhedlela eziningana, kodwa izindleko eziphakeme azizange zilethe impumuzo esimweni sakhe. Ekugcineni, waba ne-lupus nephritis kanye ne-encephalopathy, kwathi ngoSepthemba 2022, wahlinzwa ubuchopho. Lapho ezwa ukuthi ukwelashwa kwe-CAR-T kungahle kwelaphe i-SLE, uNkk. A wafuna usizo esibhedlela sethu, lapho ithimba lochwepheshe lahlaziya khona isimo sakhe ngokushesha.

Udokotela wachaza, "Lapho lesi siguli singeniswa okokuqala, sasinokuvuvukala okujwayelekile, i-proteinuria ebalulekile, kanye nama-antibodies amahle. Sasithole ukwelashwa kwendabuko kwama-hormone kanye nokucindezela amasosha omzimba, kanye nokwelashwa okuyisikhombisa kwebhayoloji, kodwa akukho okwaphumelela. Sathola i-lupus encephalopathy, umfutho wegazi ophezulu wamaphaphu, i-pulmonary fibrosis, kanye ne-biopsy yakhe yezinso yabonisa i-lupus esebenzayo. Lokhu kwabonisa ukuthi ukwelashwa kwendabuko kanye nebhayoloji kwakungasebenzi." Uma kuqhathaniswa nama-chemical agents endabuko noma ama-monoclonal antibodies, amaseli e-CAR-T angangena ezithiyweni zezicubu, asakazeke kabanzi ezicutshini, futhi abe nomphumela we-cytotoxic, ikakhulukazi ngokumelene namaseli e-B noma amaseli e-plasma ezikhaleni zezicubu ezingafinyeleleki ngama-antibody e-monoclonal. Ngaphandle 'kwembewu yesifo,' ama-autoantibodies esiguli ayancipha kancane kancane, ama-complements abuyela esimweni esijwayelekile, futhi izimpawu ziyaphela kancane kancane." Ngakho-ke, isiguli sathola ukwelashwa kwe-CAR-T ngempumelelo.

UNksz A uthe, "Manje amabala abomvu emzimbeni wami awasekho, futhi angisadingi imithi yama-hormone noma imithi yokucindezela amasosha omzimba. Bengivame ukuhlolwa igazi nomchamo njalo, kodwa manje sengikudinga njalo ezinyangeni eziyisithupha. Isimo sami sisonke sihle, futhi zonke izinkomba zijwayelekile. Namuhla ukuvakasha kwami ​​​​kwesithathu okulandelayo, futhi imiphumela yokuvakasha okubili kwangaphambilini ibimihle. Ngibonga kakhulu abasebenzi bezokwelapha ngokunginika ithuba lesibili empilweni."