I-Systemic Lupus Erythematosus (SLE)-04

Lapho eneminyaka engu-7 ubudala, uYaoyao (igama elingelona elakhe) waqala ukuqaphela ukuvela kwamaqhubu abomvu ebusweni bakhe, okwasakazeka kancane kancane emzimbeni wakhe wonke. Kanye nalezi zimpawu, waba nezilonda zomlomo eziphindaphindayo kanye nobuhlungu obuqhubekayo bamalunga, okwashukumisela umndeni wakhe ukuba ufune usizo lwezokwelapha. Ngemva kokuhlolwa kahle esibhedlela, uYaoyao watholakala enesifo se-systemic lupus erythematosus (SLE), isifo sokuzivikela komzimba esaziwa ngokuqhubeka kwaso okuyinkimbinkimbi nokungalindelekile.

Phakathi neminyaka emithathu, uYaoyao welashwa kakhulu futhi walandelwa njalo esibhedlela. Naphezu kokwanda kwemithamo yemithi esondela ezingeni eliphezulu, isimo sakhe asizange sibonise ukuthuthuka okukhulu. Ngesikhathi esifanayo, i-proteinuria yakhe, inkomba yokubandakanyeka kwezinso ku-SLE, yaqhubeka nokukhula, okubangela ukucindezeleka nokukhathazeka phakathi kwamalungu omndeni wakhe.

Ngokudluliselwa komngane othembekile, uYaoyao wethulwa kwi-BIOOCUS Medical Group, lapho ahlanganyela khona ocwaningweni lwezokwelapha oluyisiqalo lwe-CAR-T. Ngemva kwenqubo yokuhlola eqinile, wamukelwa ocwaningweni ngo-Ephreli 8. Ngemva kwalokho, ngo-Ephreli 22, waqoqwa amaseli, kwathi ngoMeyi 12, wathola ukufakwa kwamaseli aphathwe yi-CAR-T. Ukuphuma kwakhe ngempumelelo ngoMeyi 27 kwaphawula isikhathi esibalulekile ohambweni lwakhe lokwelashwa.

Phakathi nokulandelela kwakhe kwenyanga yokuqala, ochwepheshe bezokwelapha babona intuthuko enkulu, ikakhulukazi ukwehla kwe-proteinuria. Ekuhambeleni okulandelayo, ukuqubuka kwesikhumba sakhe kwase kucishe kwanyamalala, kusele ukuqubuka okuncane esihlathini sakhe sokunene. Okubaluleke kakhulu, i-proteinuria yakhe yayisiphelile ngokuphelele, kanti amaphuzu akhe e-SLE Disease Activity Index (SLEDAI-2K) abonise isimo sesifo esincane, esingaphansi kuka-2.

Eqiniswe ukusebenza kahle kokwelashwa ngamaseli e-CAR-T, uYaoyao wanciphisa kancane kancane imithi yakhe ngaphansi kokuqashwa ngokucophelela kwezokwelapha. Okuphawulekayo ukuthi ubelokhu engenamithi izinyanga ezingaphezu kwezine, okufakazela ukukhululeka okuqhubekayo okutholakale ngale ndlela yokwelapha entsha.

Uhambo lukaYaoyao lugcizelela amandla okuguqula ukwelashwa kwe-CAR-T ekuphatheni izimo ezinzima zokuzivikela komzimba njenge-SLE, okunikeza ithemba nemiphumela ebonakalayo lapho ukwelashwa kwendabuko kungase kungaphumeleli khona. Okuhlangenwe nakho kwakhe kusebenza njengesibani sethemba ezigulini nasemindenini ebhekana nezinselele ezifanayo, okubonisa ikusasa elithembisayo lemithi eyenzelwe wena ekuphathweni kwezifo zokuzivikela komzimba.