Indwara ya Systemic Lupus Erythematosus (SLE)-04

Ku myaka 7, Yaoyao (izina ry'irihimbano) yatangiye kubona ko hari uduheri dutukura mu maso, twagiye dukwirakwira mu mubiri we wose. Uretse ibyo bimenyetso, yahuye n'ibisebe byo mu kanwa bigaruka kenshi ndetse n'ububabare buhoraho mu ngingo, bituma umuryango we ujya kwa muganga. Nyuma yo gusuzumwa neza mu bitaro, Yaoyao yasanze afite indwara ya lupus erythematosus (SLE), indwara y’ubwirinzi bw’umubiri izwiho kuba igoye kandi idasobanutse neza.

Mu gihe cy'imyaka itatu, Yaoyao yavuwe cyane kandi akurikiranwa buri gihe mu bitaro. Nubwo imiti yagabanutse cyane igera ku rwego rwo hejuru, indwara ye ntiyagaragaje ko yahindutse cyane. Hagati aho, poroteyine ye, ikimenyetso cy'uko impyiko zigize ikibazo cya SLE, yakomeje kwiyongera, bitera agahinda n'impungenge mu bagize umuryango we.

Binyuze mu kohereza kwa muganga w’inshuti yizewe, Yaoyao yagejejwe muri BIOOCUS Medical Group, aho yitabiriye igerageza rikomeye rya CAR-T. Nyuma y’isuzuma rikomeye, yemerewe kwinjira muri iryo gerageza ku ya 8 Mata. Nyuma yaho, ku ya 22 Mata, yafatiwe mu itora ry’uturemangingo, naho ku ya 12 Gicurasi, ahabwa inshinge zavuwe na CAR-T. Yavuye mu bitaro ku ya 27 Gicurasi, yabaye igihe cy’ingenzi mu rugendo rwe rwo kuvurwa.

Mu kwezi kwe kwa mbere, abaganga babonye iterambere rikomeye, cyane cyane igabanuka rya poroteyine mu muyoboro w'amaraso. Mu gusurwa kwakurikiyeho, ibisebe byo ku ruhu bye byari hafi kurangira, hari hasigaye gusa ibisebe ku itama rye ry'iburyo. Icy'ingenzi ni uko poroteyine mu muyoboro w'amaraso yari yarangiye burundu, kandi amanota ye ya SLE Disease Activity Index (SLEDAI-2K) yagaragaje ko yari afite indwara yoroheje, iri munsi ya 2.

Yaoyao, atewe imbaraga n'ubushobozi bwo kuvura selile za CAR-T, yagiye agabanya imiti ye buhoro buhoro akurikiranwa neza n'abaganga. Igitangaje ni uko amaze amezi arenga ane nta miti yafashe, bigaragaza ko yagabanutse cyane binyuze muri ubu buryo bushya bwo kuvura.

Urugendo rwa Yaoyao rugaragaza ubushobozi bwo guhindura ubuvuzi bwa CAR-T mu kuvura indwara zikomeye ziterwa n’ubwiyongere bw’umubiri nka SLE, bitanga icyizere n’umusaruro ufatika aho ubuvuzi gakondo bushobora kunanirwa. Ubunararibonye bwe butanga icyizere ku barwayi n’imiryango bahangana n’ibibazo nk’ibyo, bigaragaza ahazaza heza h’ubuvuzi bwihariye mu kuvura indwara ziterwa n’ubwiyongere bw’umubiri.