Systemic Lupus Erythematosus (SLE)-04

Ali ndi zaka 7, Yaoyao (dzina lodziwika bwino) anayamba kuona ziphuphu zofiira pankhope pake, zomwe zinafalikira pang'onopang'ono m'thupi lake lonse. Kuphatikiza pa zizindikirozi, anakumana ndi zilonda zam'kamwa zomwe zinkabwera mobwerezabwereza komanso kupweteka kosalekeza kwa mafupa, zomwe zinapangitsa kuti banja lake lipite kuchipatala. Atafufuzidwa bwino kuchipatala, Yaoyao anapezeka ndi matenda a systemic lupus erythematosus (SLE), matenda odziteteza okha omwe amadziwika kuti ndi ovuta komanso osadziwikiratu.

Kwa zaka zitatu, Yaoyao adalandira chithandizo chamankhwala champhamvu komanso kutsatiridwa pafupipafupi kuchipatala. Ngakhale kuti kuchuluka kwa mankhwala kunakwera kwambiri, vuto lake silinasinthe kwenikweni. Pa nthawi yomweyo, proteinuria yake, yomwe imasonyeza kuti impso zake zili ndi vuto la SLE, idapitirira kukulirakulira, zomwe zidapangitsa kuti abale ake azivutika maganizo komanso azidandaula.

Kudzera mwa bwenzi lodalirika, Yaoyao adadziwitsidwa ku BIOOCUS Medical Group, komwe adachita nawo kafukufuku wodziwika bwino wa CAR-T. Pambuyo pa njira yowunikira mozama, adalandiridwa mu mlanduwo pa Epulo 8. Pambuyo pake, pa Epulo 22, adatengedwa maselo, ndipo pa Meyi 12, adapatsidwa maselo ochiritsidwa ndi CAR-T. Kutuluka kwake bwino pa Meyi 27 kunali nthawi yofunika kwambiri paulendo wake wochira.

Pa mwezi wake woyamba wotsatira, akatswiri azachipatala adawona kupita patsogolo kwakukulu, makamaka kuchepa kwa proteinuria. Pamaulendo otsatira, ziphuphu zake pakhungu zidatsala pang'ono kutha, ndipo ziphuphu zochepa chabe zidatsala pa tsaya lake lamanja. Chofunika kwambiri, proteinuria yake idatha kwathunthu, ndipo chiŵerengero chake cha SLE Disease Activity Index (SLEDAI-2K) chidasonyeza kuti anali ndi matenda ochepa, osakwana 2.

Atalimbikitsidwa ndi mphamvu ya chithandizo cha maselo a CAR-T, Yaoyao pang'onopang'ono anachepetsa mankhwala ake motsogozedwa ndi dokotala mosamala. Chodabwitsa n'chakuti, wakhala wopanda mankhwala kwa miyezi yoposa inayi, zomwe zikusonyeza kuti njira yatsopano yochiritsirayi yathandiza kuti matendawa apitirire.

Ulendo wa Yaoyao ukugogomezera kuthekera kosintha kwa chithandizo cha CAR-T pothana ndi matenda oopsa a chitetezo chamthupi monga SLE, kupereka chiyembekezo ndi zotsatira zooneka bwino pamene chithandizo chachikhalidwe chingalephereke. Chidziwitso chake chimapereka chiyembekezo kwa odwala ndi mabanja omwe akukumana ndi mavuto ofanana, kuwonetsa tsogolo labwino la mankhwala apadera pakuwongolera matenda a chitetezo chamthupi.