I-Systemic Lupus Erythematosus (SLE)-04

Xa wayeneminyaka esi-7 ubudala, uYaoyao (igama elingelolakhe) waqala ukuqaphela ukuvela kwamaqhuqhuva abomvu ebusweni bakhe, asasazeka kancinci emzimbeni wakhe wonke. Kunye nezi mpawu, wafumana izilonda zomlomo eziphindaphindiweyo kunye neentlungu ezingapheliyo zamalungu, nto leyo eyabangela ukuba usapho lwakhe lufune unyango. Emva kokuhlolwa ngokucokisekileyo esibhedlele, uYaoyao wafunyaniswa ene-systemic lupus erythematosus (SLE), isifo sokuzikhusela komzimba esaziwa ngokuba siyinkimbinkimbi kwaye asiqinisekanga.

Kwiminyaka emithathu, uYaoyao wafumana unyango olunzulu kunye nokulandelelana rhoqo esibhedlele. Nangona umthamo wamayeza unyuka usondela kwinqanaba eliphezulu, imeko yakhe ayizange ibonakalise ukuphucuka. Kwangaxeshanye, iproteinuria yakhe, uphawu lokubandakanyeka kwezintso kwi-SLE, yaqhubeka nokunyuka, ibangela uxinzelelo kunye nexhala kumalungu osapho lwakhe.

Ngokuthunyelwa ngumhlobo othembekileyo, uYaoyao waziswa kwi-BIOOCUS Medical Group, apho wathatha inxaxheba kuvavanyo lweklinikhi oluphambili lwe-CAR-T. Emva kwenkqubo yovavanyo oluqatha, wamkelwa kuvavanyo ngo-Aprili 8. Emva koko, ngo-Aprili 22, wathathwa iiseli, kwaye ngoMeyi 12, wafumana ukufakelwa kweeseli ezinyangiweyo ze-CAR-T. Ukukhululwa kwakhe ngempumelelo ngoMeyi 27 kwaphawula ixesha elibalulekileyo kuhambo lwakhe lonyango.

Ngexesha lokulandela kwakhe inyanga yokuqala, iingcali zonyango zaphawula inkqubela ebonakalayo, ingakumbi ukwehla kwe-proteinuria. Kwiityelelo ezilandelayo, amaqhuqhuva akhe eluswini ayesele ephelile, kukho iqhuqhuva elibuthathaka kuphela esidleleni sakhe sasekunene. Okubaluleke kakhulu kukuba, i-proteinuria yakhe yayiphelile ngokupheleleyo, kwaye amanqaku akhe e-SLE Disease Activity Index (SLEDAI-2K) abonisa imeko yesifo esincinci, esingaphantsi kwe-2.

Eqiniswa kukusebenza kakuhle kwe-CAR-T cell therapy, uYaoyao wayeka kancinci kancinci ukuyeka amayeza akhe phantsi kweliso elibukhali lezonyango. Okumangalisayo kukuba, ebengenawo amayeza kangangeenyanga ezine, nto leyo engqina ukuba uxolelo oluqhubekayo lufunyenwe ngale ndlela intsha yonyango.

Uhambo lukaYaoyao lugxininisa amandla okuguqula unyango lwe-CAR-T ekulawuleni iimeko ezinzima zokuzikhusela komzimba ezifana ne-SLE, nto leyo enika ithemba kunye neziphumo ezibonakalayo apho unyango lwendabuko lunokungaphumeleli. Amava akhe asebenza njengokukhanya kwethemba kwizigulana nakwiintsapho ezijongene nemingeni efanayo, ebonisa ikamva elithembisayo lonyango lomntu ngamnye ekulawuleni izifo zokuzikhusela komzimba.