I-Systemic Lupus Erythematosus (SLE)-03

Ngo-Agasti 2016, uNksz A oneminyaka engama-20 ubudala waba namabala amancinci abomvu emzimbeni wakhe wonke kunye nomkhuhlane oqhelekileyo, kwaye wayene-platelet counts ephantsi, emva kweenyanga ezisixhenxe ebelethile. Emva kokuhlolwa izihlandlo ezininzi kwizibhedlele zasekuhlaleni, wafunyaniswa ene-systemic lupus erythematosus (SLE) kwisibhedlele sephondo. Ngo-Okthobha waloo nyaka mnye, waqala ukufumana unyango kwisibhedlele sakhe sasekuhlaleni.

“Kwiminyaka esixhenxe edlulileyo, bekufuneka ndityelele isibhedlele inyanga nenyanga ukuze ndifumane amayeza, uvavanyo lwegazi rhoqo, uvavanyo lomchamo, kunye namayeza kunye neenaliti rhoqo, kodwa imeko ibisoloko iphindaphinda, nto leyo eyayibuhlungu kakhulu,” utshilo uNksz A. Ezama ukunyanga isifo sakhe, umyeni wakhe wamsa kwizibhedlele ezininzi, kodwa iindleko eziphezulu azizange zimncede kwimeko yakhe. Ekugqibeleni, waba ne-lupus nephritis kunye ne-encephalopathy, kwaye ngoSeptemba 2022, wenza utyando lobuchopho. Akuva ukuba unyango lwe-CAR-T lunokunyanga i-SLE, uNksz A wafuna uncedo kwisibhedlele sethu, apho iqela leengcali lahlalutya imeko yakhe ngoko nangoko.

Ugqirha wachaza wathi, "Xa esi sigulana saqala ukungeniswa, sasinokuvuvukala okuqhelekileyo, iproteinuria ebalulekileyo, kunye nee-antibodies ezilungileyo. Sasifumene unyango lwe-hormone kunye ne-immunosuppressive, kunye nonyango lwebhayoloji oluphindwe kasixhenxe, kodwa akukho nanye eyasebenzayo. Safumana i-lupus encephalopathy, uxinzelelo lwegazi oluphezulu lwe-pulmonary, i-pulmonary fibrosis, kwaye i-renal biopsy yaso yabonisa i-lupus esebenzayo. Oku kubonise ukuba unyango lwendabuko nolwebhayoloji aluzange luphumelele." Xa kuthelekiswa nee-chemical agents zendabuko okanye ii-monoclonal antibodies, ii-CAR-T cells zinokungena kwiingxaki zezicubu, zisasazeke ngokubanzi kwizicubu, kwaye zibe nefuthe le-cytotoxic, ngakumbi kwii-B cells okanye ii-plasma cells kwizithuba zezicubu ezingafikelelekiyo zii-monoclonal antibodies. Ngaphandle 'kwembewu yesifo,' ii-autoantibodies zesigulana ziyancipha kancinci kancinci, izakhi zibuyela kwisiqhelo, kwaye iimpawu ziyaphela kancinci kancinci." Ke ngoko, isigulana safumana ngempumelelo unyango lwe-CAR-T.

UNksz A uthe, "Ngoku amabala abomvu emzimbeni wam aphelile, kwaye andisawadingi amayeza eehomoni okanye amayeza okunciphisa amajoni omzimba. Bendisoloko ndivavanywa igazi nomchamo rhoqo, kodwa ngoku ndiwadinga rhoqo emva kweenyanga ezintandathu. Imeko yam iyonke ilungile, kwaye zonke izalathiso ziqhelekile. Namhlanje lutyelelo lwam lwesithathu lokulandelela, kwaye iziphumo zotyelelo lwam oludlulileyo bezilungile. Ndibulela kakhulu abasebenzi bezonyango ngokundinika ithuba lesibini ebomini."