Indwara ya Systemic Lupus Erythematosus (SLE)-03

Muri Kanama 2016, Madamu A w'imyaka 20 yagize utudomo duto dutukura ku mubiri we wose ndetse akagira umuriro ukabije, kandi yagize umubare muto w'udukoko two mu maraso, nyuma y'amezi arindwi abyaye. Nyuma yo gusuzumwa kenshi mu bitaro byo muri ako gace, yasanze afite indwara ya lupus erythematosus (SLE) mu bitaro byo mu ntara. Mu Ukwakira k'uwo mwaka, yatangiye kuvurirwa mu bitaro byo muri ako gace.

Madamu A yagize ati: "Mu myaka irindwi ishize, nagombaga kujya kwa muganga buri kwezi kugira ngo bankorere imiti, banpime amaraso kenshi, banpime inkari, bankoreshe imiti n'inshinge buri gihe, ariko iyo ndwara yakomeje kugaruka, byari bibabaje cyane." Mu rwego rwo kuvura indwara ye, umugabo we yamujyanye mu bitaro byinshi, ariko ibiciro byari hejuru ntibyamufashije kugabanya ububabare bwe. Amaherezo, yarwaye indwara ya lupus nephritis na encephalopathy, maze muri Nzeri 2022, abagwa ubwonko. Amaze kumva ko ubuvuzi bwa CAR-T bushobora kuvura SLE, Madamu A yashatse ubufasha mu bitaro byacu, aho itsinda ry'inzobere ryahise risesengura ikibazo cye.

Muganga yasobanuye agira ati: "Ubwo uyu murwayi yakirwaga bwa mbere, yari afite indwara yo kubyimba mu mubiri, poroteyine nyinshi, n'uturemangingo twa antibodies twagaragaye. Yari yarahawe imiti gakondo igabanya ubukana bw'umubiri n'imisemburo, ndetse n'ubuvuzi bw'umubiri inshuro ndwi, ariko nta na kimwe cyagize ingaruka nziza. Yarwaye indwara ya lupus encephalopathy, umuvuduko ukabije w'amaraso mu bihaha, fibrosis y'ibihaha, kandi biopsy ye y'impyiko yagaragaje ko ikora lupus. Ibi byagaragaje ko ubuvuzi gakondo n'ubw'umubiri ntacyo bwagezeho." Ugereranije n'imiti gakondo cyangwa uturemangingo twa monoclonal, uturemangingo twa CAR-T dushobora kwinjira mu nzitizi z'uturemangingo, tugakwirakwira cyane mu turemangingo, kandi tukagira ingaruka mbi ku turemangingo, cyane cyane ku turemangingo twa B cyangwa uturemangingo twa plasma mu cyuho cy'uturemangingo tudashobora kugerwaho na uturemangingo twa monoclonal. Iyo hatabayeho 'imbuto z'indwara,' uturemangingo tw'umubiri tw'umurwayi turagabanuka buhoro buhoro, uturemangingo twongera kumera neza, kandi ibimenyetso bigahita bigabanuka buhoro buhoro." Kubwibyo, umurwayi yakiriye neza ubuvuzi bwa CAR-T.

Madamu A yagize ati: "Ubu ibisebe bitukura ku mubiri wanjye byarashize, kandi ntabwo nkikeneye imiti igabanya imisemburo cyangwa imiti igabanya ubudahangarwa bw'umubiri. Najyaga npimwa amaraso n'inkari kenshi, ariko ubu mbikeneye buri mezi atandatu gusa. Imiterere yanjye muri rusange ni myiza, kandi ibimenyetso byose ni ibisanzwe. Uyu munsi ni uwa gatatu nkurikira, kandi ibisubizo byo gusura kabiri byari byiza. Ndashimira cyane abakozi b'abaganga bampaye amahirwe yo kubaho ukundi."