Systemic Lupus Erythematosus (SLE)-03

Mu Ogasiti 2016, Ms. A wazaka 20 anayamba kukhala ndi mawanga ofiira thupi lonse komanso kutentha thupi pafupipafupi, ndipo anali ndi ma platelet ochepa, miyezi isanu ndi iwiri atabereka. Atapimidwa kangapo m'zipatala zakomweko, anapezeka ndi matenda a systemic lupus erythematosus (SLE) m'chipatala cha boma. Mu Okutobala chaka chomwecho, anayamba kulandira chithandizo kuchipatala chake chakomweko.

"Kwa zaka zisanu ndi ziwiri zapitazi, ndakhala ndikupita kuchipatala mwezi uliwonse kuti ndikalandire mankhwala, magazi pafupipafupi, kuyezetsa mkodzo, ndi mankhwala ndi jakisoni nthawi zonse, koma vutoli linkapitirira, zomwe zinali zopweteka kwambiri," adatero Mayi A. Pofuna kuchiza matenda ake, mwamuna wake anamutengera kuzipatala zingapo, koma ndalama zambiri sizinamuthandize. Pomaliza pake, anayamba lupus nephritis ndi encephalopathy, ndipo mu Seputembala 2022, anachitidwa opaleshoni ya ubongo. Atamva kuti chithandizo cha CAR-T chingathe kuchiza SLE, Mayi A anapempha thandizo kuchipatala chathu, komwe gulu la akatswiri linafufuza nthawi yomweyo vuto lake.

Dokotalayo anafotokoza kuti, "Pamene wodwalayu analowa m'chipatala koyamba, anali ndi kutupa kwa thupi lonse, proteinuria yofunikira, ndi ma antibodies abwino. Analandira chithandizo cha mahomoni ndi chitetezo chamthupi, komanso chithandizo chamankhwala chamankhwala cha nthawi zisanu ndi ziwiri, koma palibe chomwe chinagwira ntchito. Anapeza lupus encephalopathy, kuthamanga kwa magazi m'mapapo, pulmonary fibrosis, ndipo biopsy yake ya impso inasonyeza kuti ali ndi lupus yogwira ntchito. Izi zinasonyeza kuti chithandizo chamankhwala chachikhalidwe ndi chachilengedwe sichinali chogwira ntchito." Poyerekeza ndi mankhwala achikhalidwe kapena ma antibodies a monoclonal, maselo a CAR-T amatha kulowa m'mitsempha, kufalikira kwambiri m'maselo, ndikuwonetsa poizoni, makamaka motsutsana ndi maselo a B kapena maselo a plasma m'mipata ya minofu yomwe singafikire ndi ma antibodies a monoclonal. Popanda 'mbewu za matenda,' ma antibodies a wodwalayo amachepa pang'onopang'ono, zowonjezera zimabwerera mwakale, ndipo zizindikiro zimachepa pang'onopang'ono kapena kuzimiririka." Chifukwa chake, wodwalayo adalandira chithandizo cha CAR-T bwino.

Mayi A anati, "Tsopano mawanga ofiira pathupi langa atha, ndipo sindikufunanso mankhwala a mahomoni kapena mankhwala oletsa chitetezo chamthupi. Ndinkapita kukayezetsa magazi ndi mkodzo pafupipafupi, koma tsopano ndimawafuna miyezi isanu ndi umodzi yokha. Mkhalidwe wanga wonse ndi wabwino, ndipo zizindikiro zonse ndi zabwinobwino. Lero ndi ulendo wanga wachitatu wotsatira, ndipo zotsatira za maulendo awiri apitawo zinali zabwino. Ndikuyamikira kwambiri ogwira ntchito zachipatala chifukwa chondipatsa mwayi wina wachiwiri pa moyo."