Systemic Lupus Erythematosus (SLE)-04

Pazera remakore manomwe, Yaoyao (zita rekunyepedzera) akatanga kuona kubuda kwemapundu matsvuku pachiso chake, ayo akapararira zvishoma nezvishoma mumuviri wake wese. Pamwe chete nezviratidzo izvi, akasangana nemaronda emuromo anodzokororwa uye marwadzo emapfundo asingaperi, zvikaita kuti mhuri yake iende kunotsvaga rubatsiro rwechiremba. Mushure mekuongororwa kwakanyatsoitwa kuchipatara, Yaoyao akaonekwa aine chirwere chesystemic lupus erythematosus (SLE), chirwere chinodzivirira muviri chinozivikanwa nekuoma kwacho uye chisingatarisirwi.

Mukati memakore matatu, Yaoyao akarapwa zvakanyanya uye akaongororwa nguva nenguva kuchipatara. Kunyangwe mishonga yakawedzera zvakanyanya, mamiriro ake haana kuratidza kuvandudzika zvakanyanya. Panguva imwe chete, proteinuria yake, chiratidzo chekubatwa kweitsvo muSLE, yakaramba ichikwira, zvichikonzera kushungurudzika uye kunetseka pakati pemhuri yake.

Kuburikidza nekutumirwa kweshamwari yaaivimba nayo, Yaoyao akaunzwa kuBIOOCUS Medical Group, kwaakapinda muongororo yekiriniki yeCAR-T. Mushure mekuongorora kwakasimba, akagamuchirwa muongororo iyi musi wa8 Kubvumbi. Zvadaro, musi wa22 Kubvumbi, akatorwa masero, uye musi wa12 Chivabvu, akapinzwa masero akarapwa neCAR-T. Kubuda kwake zvakanaka musi wa27 Chivabvu kwakaratidza nguva inokosha murwendo rwake rwekurapwa.

Mumwedzi wake wekutanga wekutevera, vanachiremba vakaona kufambira mberi kukuru, kunyanya kudzikira kweproteinuria. Pakushanya kwake kwakatevera, mapundu eganda rake akanga ava kuda kunyangarika, mapundu mashoma chete asara padama rake rekurudyi. Chinonyanya kukosha ndechekuti proteinuria yake yakanga yapera zvachose, uye mamakisi ake eSLE Disease Activity Index (SLEDAI-2K) akaratidza mamiriro echirwere asina kusimba, ari pasi pe2.

Achibatsirwa nekushanda kweCAR-T cell therapy, Yaoyao akaderedza zvishoma nezvishoma mishonga yake achitarisirwa nachiremba. Zvinoshamisa kuti ave asina mishonga kwemwedzi inopfuura mina, zvichiratidza kuti awana zororo rakawanda kuburikidza nenzira iyi itsva yekurapa.

Rwendo rwaYaoyao runosimbisa kugona kwekurapa kweCAR-T mukurapa zvirwere zvakakomba zve autoimmune seSLE, zvichipa tariro nemigumisiro inooneka apo kurapwa kwechinyakare kunogona kusashanda zvakanaka. Ruzivo rwake rwunoshanda sechiratidzo chetariro kune varwere nemhuri vari kutarisana nematambudziko akafanana, zvichiratidza remangwana rakanaka remishonga yakagadzirirwa munhu mukurapa zvirwere zve autoimmune.