ʻO ka Lupus Erythematosus Pūnaehana (SLE)-04

I ka piha ʻana o nā makahiki 7, ua hoʻomaka ʻo Yaoyao (he inoa kapakapa) e ʻike i ka puka ʻana mai o nā ʻulaʻula ma kona maka, ka mea i laha mālie a puni kona kino. Ma waho aʻe o kēia mau hōʻailona, ​​ua ʻike ʻo ia i nā ʻeha waha e hoʻi hou ana a me nā ʻeha hui mau, e koi ana i kona ʻohana e ʻimi i ke kōkua lapaʻau. Ma hope o nā hoʻokolokolo piha ʻana ma ka haukapila, ua ʻike ʻia ʻo Yaoyao me ka systemic lupus erythematosus (SLE), kahi maʻi autoimmune i ʻike ʻia no kona ʻano paʻakikī a hiki ʻole ke wānana.

I loko o ʻekolu mau makahiki, ua mālama ʻia ʻo Yaoyao i ka lāʻau lapaʻau koʻikoʻi a me nā nānā mau ʻana ma ka haukapila. ʻOiai ua piʻi aʻe ka nui o nā lāʻau lapaʻau i ko lākou kiʻekiʻe loa, ʻaʻole i hōʻike iki kona kūlana i ka hoʻomaikaʻi ʻana. I ka manawa like, ua hoʻomau ka piʻi ʻana o kāna proteinuria, kahi hōʻailona o ka pili ʻana o ka puʻupaʻa i ka SLE, e hoʻoulu ai i ka pilikia a me ka hopohopo i waena o kona ʻohana.

Ma o ke kuhikuhi ʻana a kahi hoaaloha hilinaʻi, ua hoʻolauna ʻia ʻo Yaoyao i ka BIOOCUS Medical Group, kahi i komo ai ʻo ia i kahi hoʻokolohua lapaʻau CAR-T hou loa. Ma hope o ke kaʻina loiloi koʻikoʻi, ua ʻae ʻia ʻo ia i ka hoʻokolohua ma ʻApelila 8. Ma hope mai, ma ʻApelila 22, ua hōʻiliʻili ʻia ʻo ia i nā cell, a ma Mei 12, ua loaʻa iā ia ka hoʻokomo ʻana o nā cell i mālama ʻia me CAR-T. ʻO kona hoʻokuʻu kūleʻa ʻana ma Mei 27 ua hōʻailona i kahi manawa koʻikoʻi i kāna huakaʻi lapaʻau.

I kona malama mua ʻana, ua ʻike nā kauka lapaʻau i ka holomua nui, ʻo ia hoʻi ka emi ʻana o ka proteinuria. I nā kipa ma hope mai, ua aneane nalowale kona mau ʻōhū ʻili, me kahi ʻōhū palupalu wale nō i koe ma kona papālina ʻākau. ʻO ka mea nui, ua pau loa kona proteinuria, a ua hōʻike kāna helu SLE Disease Activity Index (SLEDAI-2K) i kahi maʻi maʻi iki, ʻaʻole i emi ma mua o 2.

Ma muli o ka pono o ka lāʻau lapaʻau CAR-T cell, ua hoʻemi mālie ʻo Yaoyao i kāna mau lāʻau lapaʻau ma lalo o ka nānā pono ʻana a ke kauka. ʻO ka mea kupaianaha, ua ʻole ʻo ia i ka lāʻau lapaʻau no ʻehā mahina a ʻoi, e hōʻike ana i ka hoʻomau ʻia o ke kala ʻana i loaʻa ma o kēia ʻano lapaʻau hou.

Hōʻike ka huakaʻi a Yaoyao i ka hiki ke hoʻololi o ka lāʻau lapaʻau CAR-T i ka hoʻokele ʻana i nā kūlana autoimmune koʻikoʻi e like me SLE, e hāʻawi ana i ka manaʻolana a me nā hopena hiki ke ʻike ʻia kahi e hiki ʻole ai i nā lāʻau kuʻuna ke kūleʻa. Hana ʻia kāna ʻike ma ke ʻano he kukui o ka manaʻolana no nā maʻi a me nā ʻohana e hoʻokele ana i nā pilikia like, e hōʻike ana i ka wā e hiki mai ana o ka lāʻau lapaʻau pilikino i ka hoʻokele maʻi autoimmune.