ʻO ka Lupus Erythematosus Pūnaehana (SLE)-01

Ua aʻo ʻo Xiaohuan, he 24 ona makahiki, i ke kauka ma ke kulanui no ʻekolu makahiki a ua ʻeha ʻo ia i ka maʻi lupus erythematosus (SLE) no kahi kokoke i 10 mau makahiki. "Ua ʻike ʻia koʻu maʻi i ka makahiki 10, a ua ʻōlelo ke kauka he paʻakikī loa ke ho'ōla, hiki iaʻu ke kāohi wale me ka lāʻau lapaʻau," wahi a Xiaohuan me ka minoʻaka ʻawaʻawa. I loko o nā makahiki he ʻumi i hala iho nei, pono ʻo ia e hele i nā nānā mahina a me nā lāʻau lapaʻau, a ua hana ʻo ia i ka lāʻau lapaʻau hormone, immunosuppressive therapy, a me biological therapy, akā ʻaʻohe mea i kūpono. Ua ʻeha nui ʻo ia i ka hāʻule ʻana o ka lauoho, nā ʻōhū he nui, nā kuni kiʻekiʻe e hoʻi hou ana, a me ka ʻeha ākea.

Ma hope o nā hoʻokolohua mua like ʻole, ua hoʻokō ʻo Xiaohuan i nā kūlana lapaʻau āpau no ka lāʻau CAR-T no SLE. Ua hoʻolālā pono kahi hui loea i kahi hoʻolālā lapaʻau e pili ana i kona kūlana a ua hoʻomākaukau pono no ke kaʻina hana hōʻiliʻili cell. Ma Malaki 28, ua hoʻomaka ka hōʻiliʻili cell mononuclear. Ma ʻApelila 22, ua hoʻomaka ʻo ia i ka chemotherapy lymphodepleting. Ma ʻApelila 28, ua hoʻokomo hou ʻia nā cell. He iwakālua miliona mau cell T i hoʻololi ʻia e CAR i hoʻokomo mālie ʻia i loko o ke aʻa o Xiaohuan, e kuhikuhi pololei ana i nā cell lupus B, e hoʻomaka ana i kahi kaua "hoʻouka pololei, e uhaʻi iā lākou hoʻokahi".

Ma Iune 4, ʻo ia ka lā 38 ma hope o ke kāwili ʻana, ua hoʻi ʻo Xiaohuan i ka haukapila no kahi nānā hou ʻana. Ua hōʻike nā hopena o ka hoʻokolokolo ʻana ua hāʻule nā ​​​​​​hōʻailona koʻikoʻi a pau i nā pae maʻamau. "ʻAʻole pono hou iaʻu nā lāʻau lapaʻau hormone; me he mea lā e hoʻomaka wale ana ke ola," wahi a Xiaohuan me ka hauʻoli.