Lupus Erythematosus oo nidaamsan (SLE)-01

Xiaohuan oo 24 jir ah ayaa muddo saddex sano ah ka baraneysay jaamacad, waxayna la ildarnayd cudurka lupus erythematosus (SLE) muddo ku dhow 10 sano. "Waxaa la i ogaaday markii aan jiray 10 sano, dhakhtarkuna wuxuu yiri way igu adag tahay in la daaweeyo, inaan ku xakameyn karo oo keliya daawo," ayuu yiri Xiaohuan isagoo dhoola cadeynaya. Tobankii sano ee la soo dhaafay, waxay ahayd inay tagto baaritaanno bille ah iyo daawooyin, waxayna qaadatay daaweynta hoormoonka, daaweynta difaaca jirka oo yaraata, iyo daaweynta bayoolojiga, laakiin midkoodna ma uusan waxtar lahayn. Waxay la kulantay timo lumis daran, finan badan, qandho sare oo soo noqnoqda, iyo xanuun baahsan.

Ka dib baaritaanno hordhac ah oo kala duwan, Xiaohuan waxay buuxisay dhammaan shuruudaha caafimaad ee daaweynta CAR-T ee SLE. Koox khabiir ah ayaa si taxaddar leh u qaabaysay qorshe daaweyn oo ku salaysan xaaladdeeda waxayna si taxaddar leh ugu diyaar garowday habka ururinta unugyada. Maarso 28, ururinta unugyada mononuclear-ka ayaa bilaabatay. Abriil 22, waxay bilowday daaweynta kiimoterabiga lymphodepleting. Abriil 28, unugyada ayaa dib loo geliyay. Labaatan milyan oo unugyada T-ga ee CAR-ka wax laga beddelay ayaa si tartiib tartiib ah loogu shubay xididka Xiaohuan, iyagoo si toos ah u bartilmaameedsanaya unugyada lupus B, iyagoo bilaabay dagaal "weerar sax ah, mid mid u jebi".

Juun 4, oo ah maalintii 38aad ee tallaalka ka dib, Xiaohuan wuxuu ku soo laabtay isbitaalka si loola socdo. Natiijooyinka baaritaanka ayaa muujiyay in dhammaan tilmaamayaasha muhiimka ah ay hoos ugu dhaceen heerarka caadiga ah. "Uma baahni daawooyinka hoormoonka; waxay dareemeysaa in noloshu ay hadda bilaabaneyso," Xiaohuan ayaa si farxad leh u yiri.