Kab mob Lupus Erythematosus (SLE)-01

Xiaohuan uas muaj hnub nyoog 24 xyoo tau kawm txog tshuaj hauv tsev kawm ntawv qib siab tau peb xyoos thiab tau raug kev txom nyem los ntawm tus kab mob systemic lupus erythematosus (SLE) yuav luag 10 xyoo. "Kuv tau kuaj pom tias muaj mob thaum muaj hnub nyoog 10 xyoo, thiab tus kws kho mob hais tias nws nyuaj heev rau kho, tias kuv tsuas yog tswj tau nws nrog tshuaj," Xiaohuan hais nrog luag nyav. Tau kaum xyoo dhau los, nws yuav tsum mus kuaj mob txhua hli thiab sau ntawv yuav tshuaj, thiab nws tau txais kev kho mob hormone, kev kho mob tiv thaiv kab mob, thiab kev kho mob biological, tab sis tsis muaj ib qho zoo. Nws tau nyiaj dhau los ntawm kev poob plaub hau hnyav, ntau pob khaus, kub taub hau rov qab los, thiab mob kis thoob plaws.

Tom qab ntau qhov kev kuaj mob ua ntej, Xiaohuan tau ua tiav txhua yam kev kuaj mob rau CAR-T kho mob SLE. Ib pab neeg kws tshaj lij tau tsim ib txoj kev npaj kho mob raws li nws tus mob thiab npaj ua tib zoo rau cov txheej txheem sau cov cell. Thaum Lub Peb Hlis 28, kev sau cov cell mononuclear tau pib. Thaum Lub Plaub Hlis 22, nws tau pib siv tshuaj chemotherapy lymphodepleting. Thaum Lub Plaub Hlis 28, cov cell tau rov muab tso rau hauv. Nees nkaum lab CAR-modified T cell tau maj mam muab tso rau hauv Xiaohuan cov leeg ntshav, ncaj qha rau cov cell lupus B, pib "kev tawm tsam meej, rhuav tshem lawv ib qho los ntawm ib qho" kev sib ntaus.

Thaum Lub Rau Hli 4, hnub thib 38 tom qab txhaj tshuaj, Xiaohuan rov qab mus rau tsev kho mob kom rov qab mus saib dua. Cov txiaj ntsig ntawm kev kuaj mob qhia tias txhua yam tseem ceeb tau poob qis mus rau qhov qub. "Kuv tsis xav tau cov tshuaj hormones lawm; nws zoo li lub neej nyuam qhuav pib," Xiaohuan hais zoo siab.