Myeloma nyinshi hamwe na Extramedullary Plasmacytoma

Ibi ni ibyagaragaye ku murwayi w’umugabo w’imyaka 73 wafashwe na myeloma nyinshi, bikoroha bitewe no kuba hari plasmacytoma isanzwe. Mu gihe cyose cyo kuvurwa na Dara-VRD (Daratumumab, Bortezomib, Lenalidomide, Dexamethasone), plasmacytoma isanzwe yakomeje kugaragara, itera ububabare bukomeye n’umubabaro ku murwayi.

Ukurikije imiterere ikomeye y’iyi ndwara no kutagira igisubizo ku miti isanzwe, umurwayi yiyandikishije mu igerageza rya muganga ku buvuzi bwa BCMA CAR-T. Nyuma yo gukora ingamba zikenewe zo kwitegura, harimo no gukuraho lymphodepletion, umurwayi yahawe selile za BCMA CAR-T.

Igitangaje ni uko mu minsi 10 nyuma yo guterwa, umurwayi yagize ikibazo cyo kubura amaraso mu mubiri (CRS) ku rwego rwa kabiri, bigaragaza ko ubudahangarwa bw'umubiri bukora neza. Byongeye kandi, hari CRS nyinshi yagaragaye aho plasmacytoma yavuye.

Igitangaje kurushaho ni uko muri iki gihe gito, igisebe cyo hanze y’umugongo cyari kidakira kuvurwa mbere, cyari cyaragaragaye ko kidakira imiti myinshi, imiti yagenewe, n’uturemangingo tw’umubiri two mu bwoko bwa monoclonal, cyarashize burundu. Umurwayi yakize burundu, bigaragaza ko ubuvuzi bwagenze neza.

Mu gihe cyose cyo kuvurwa, itsinda ry’abaganga ryakurikiraniraga hafi umurwayi kugira ngo barebe ibimenyetso by’ingaruka mbi kandi bamuha ubuvuzi busesuye. Ibi birimo kuvura ibimenyetso bya CRS no gukemura izindi ngorane zose zijyanye n’ubuvuzi.

Uko ubuvuzi bwakomeje, itsinda ry’abaganga ryakomeje gukurikirana hafi uko umurwayi yitabira ubuvuzi bwa BCMA CAR-T. Hakozwe isuzuma rihoraho kugira ngo harebwe akamaro k’ubuvuzi no gukemura ingaruka mbi zigaragara vuba.

Nyuma yo koroherwa cyane, ubuzima bw'umurwayi bwarushijeho kuba bwiza, aho ububabare n'imibabaro bijyana na plasmacytoma yo hanze y'umugongo bigabanuka. Ubwo iyi ndwara yari imaze kugenzurwa, umurwayi yashoboye gusubira mu mirimo ye ya buri munsi no kugira ubuzima bwiza muri rusange.

Byongeye kandi, kubera ko twabonye akamaro ko gukurikirana umurwayi igihe kirekire, itsinda ryacu ry’abaganga ryakomeje kugira uruhare runini mu rugendo rwe nyuma yo kuvurwa. Hashyizweho gahunda yo gukurikirana umurwayi buri gihe kugira ngo barebe uko amerewe, barebe uko abyakira neza, kandi barebe niba ashobora kongera kurwara cyangwa ingaruka mbi zishobora kumubaho nyuma y’igihe gito.

Uretse gukurikirana ubuvuzi, ikigo cyacu cyatanze serivisi zuzuye zo gufasha umurwayi kumenyera ubuzima nyuma yo kuvurwa. Ibi birimo kubona serivisi z'ubujyanama, gahunda zo kugarura ubuzima, n'amasomo yo kwigisha kugira ngo bifashe umurwayi n'umuryango we kurokoka no kugira ubuzima bwiza.

Ibisubizo byavuye muri uru rubanza bigaragaza neza akamaro k’ubuvuzi bwa BCMA CAR-T mu kuvura indwara ya myeloma nyinshi idakira, ahubwo binagaragaza akamaro ko kwita ku bantu ku giti cyabo no mu nzego zitandukanye mu kuvura kanseri ikomeye y’amaraso. Umuhango wacu wo gutanga ubufasha buhoraho no gukurikirana ubuvuzi ugaragaza ubwitange bwacu mu kwemeza ko abarwayi bacu bazagerwaho n’ingaruka nziza nyuma y’igihe cyo kuvurwa.

Mbere na nyuma y'amezi 3 yo guterwa