Bwana D----Isuzuma ry'Abanyakanada: Lymphoma nini ya B-cell (DLBCL) ikwirakwira hamwe n'impinduka za TP53

Twe, nk'ikigo cy'ubuvuzi, twagize amahirwe yo kuvura umurwayi witwa Bwana D, ukomoka muri Kanada. Yasuzumwe indwara ya Diffuse Large B-cell Lymphoma (DLBCL) ifite TP53 mutation, indwara yateye imbogamizi zikomeye ku buryo gakondo bwo kuvura.

Bwana D yatangiye urugendo rwe rwo kurwanya iyi ndwara ikomeye afite icyizere n'ubushake biranga imiterere ye. Mbere na mbere, yakorewe imiti ya R-CHOP yo ku rwego rwa mbere, uburyo busanzwe bwo kuvura DLBCL. Nubwo hari icyizere cya mbere, kugerageza kwakurikiyeho ku buryo bwo kuvura bwo ku rwego rwa kabiri nka R-DHAP na GEMOX-BTKi ntibyatanze umusaruro, bituma indwara ye ikomeza kumera nabi, bituma Bwana D n'itsinda rye ry'abaganga bababaye cyane.

Tumaze kubona ko ikibazo cyihutirwa kandi ko hakenewe ibisubizo bishya, twafashe icyemezo cyo gushyira Bwana D muri gahunda yo kuvura CD19-CAR-T. Ubu buryo bugezweho bwo kuvura kanseri bukoresha imbaraga z'ubudahangarwa bw'umubiri mu kwibasira no gusenya uturemangingo twa kanseri, bitanga icyizere ku barwayi nka Bwana D barangije uburyo busanzwe bwo kuvura.

Ibisubizo byari bitangaje cyane. Nyuma y'ukwezi kumwe gusa habayeho guteranya uturemangingo twa CD19-CAR-T, Bwana D yageze ku ndunduro yuzuye, igikorwa cyasaga n'aho kidashoboka mu byumweru bike mbere yaho. Ariko, uru rugendo rwo kugabanya ububabare ntirwari rudafite imbogamizi. Bwana D yahuye n'indwara yo mu cyiciro cya kabiri cy'imiti ya cytokine (CRS) na immunotoxicity syndrome yo mu cyiciro cya mbere cy'imiti ya immuno effect cell (ICANS) mu gihe cyo kuvurwa. Ku bw'amahirwe, itsinda ryacu ry'abaganga ryari ryihutiye kuvura, rikemura neza izi ngorane rikoresheje tocilizumab, adalimumab, no kuvura imisemburo, rituma Bwana D yumva afite umutekano kandi amerewe neza mu gihe cyose cy'ubuvuzi.

Ingufu za CAR-T therapy ku barwayi ba D barwaye DLBCL ku isi yose ni urumuri rw'icyizere, bigaragaza ubushobozi bwo guhindura uburyo bw'ubu buryo bw'ubuvuzi bugezweho. Byongeye kandi, urugendo rwa Bwana D rugaragaza uruhare rw'ingenzi rw'ubufatanye mu nzego zitandukanye no kwita ku barwayi mu buryo bw'impuhwe mu kurwanya kanseri.

Atekereza ku byo yabonye, ​​Bwana D yashimiye cyane inkunga n'ubuhanga bw'ikipe ye y'abaganga. Yagize ati: "Urwego rw'ubuvuzi n'ubwitange nahawe mu gihe cyose cy'ubuvuzi bwanjye ntagereranywa. Ntabwo bavuje indwara yanjye gusa, ahubwo bananyitayeho ku byo nkeneye mu marangamutima no mu mirire, banyemeza ko numva nshyigikiwe muri buri ntambwe."

Inkuru ya Bwana D ni igihamya cy'uko umwuka w'umuntu uhagaze neza ndetse n'iterambere ritangaje riri guterwa mu rwego rwa kanseri. Uko dukomeza gutera imbere mu guhanga udushya mu buvuzi, dukomeje kwiyemeza gutanga ubuvuzi bwihariye kandi burangwa n'impuhwe kuri buri murwayi wese uduhaye inshingano zo kwita ku buzima bwe n'imibereho myiza ye.

Mu ntangiriro z'indwara n'umunsi umwe mbere yayo n'ukwezi kumwe nyuma yo kuyitera.