UMnu. D----Ukuxilongwa KwaseCanada: I-Diffuse Large B-cell Lymphoma (DLBCL) ene-TP53 mutation

Thina, njengesikhungo sezokwelapha, saba nelungelo lokwelapha isiguli esibizwa ngokuthi uMnu. D, odabuka eCanada. Watholakala ene-Diffuse Large B-cell Lymphoma (DLBCL) ene-TP53 mutation, isimo esasibeka izinselele ezinkulu ezindleleni zokwelapha zendabuko.

UMnu. D waqala uhambo lwakhe lokulwa nalesi sifo esibi kakhulu enethemba nokuzimisela okufana nobuntu bakhe. Ekuqaleni, welashwa nge-R-CHOP chemotherapy yomugqa wokuqala, inqubo yokwelapha ejwayelekile ye-DLBCL. Naphezu kwamathemba okuqala, imizamo eyalandela yokwelashwa komugqa wesibili njenge-R-DHAP kanye ne-GEMOX-BTKi ayizange iphumelele, okwenza isimo sakhe saba sibi kakhulu, okwadumaza uMnu. D kanye nethimba lakhe lezokwelapha.

Siqaphela ukuphuthuma kwalesi simo kanye nesidingo sezixazululo ezintsha, sathatha isinqumo sokufaka uMnu. D ohlelweni lokwelapha i-CD19-CAR-T. Le ndlela esezingeni eliphezulu yokwelapha umdlavuza isebenzisa amandla esimiso somzimba sokuzivikela komzimba ukuhlasela nokubhubhisa amangqamuzana omdlavuza, okunikeza ithemba ezigulini ezinjengoMnu. D eseziqede izindlela zokwelapha ezivamile.

Imiphumela yayimangalisa kakhulu. Ngemva kwenyanga eyodwa nje kokufakwa kwamaseli e-CD19-CAR-T, uMnu. D wakwazi ukukhululeka ngokuphelele, into eyayibonakala ingenakwenzeka emasontweni ambalwa ngaphambili. Kodwa-ke, lolu hambo oluya ekuphumuleni lwalunezinselele zalo. UMnu. D wabhekana ne-intermediate-grade cytokine release syndrome (CRS) kanye ne-grade 1 immune effector cell-associated neurotoxicity syndrome (ICANS) ngesikhathi sokwelashwa. Ngenhlanhla, ithimba lethu lezokwelapha eliqaphile langenelela ngokushesha, laphatha ngempumelelo lezi zinkinga nge-tocilizumab, i-adalimumab, kanye nokwelashwa ngama-hormone, laqinisekisa ukuphepha nenduduzo kaMnu. D kuyo yonke inqubo.

Ukusebenza kahle kokwelashwa kwamaseli e-CAR-T ecaleni likaMnu. D kusebenza njengesibani sethemba ezigulini ze-DLBCL ezingalapheki emhlabeni wonke, okubonisa amandla okuguqula ale ndlela yokwelapha ephawulekayo. Ngaphezu kwalokho, uhambo lukaMnu. D luqokomisa indima ebalulekile yokusebenza ngokubambisana kwemikhakha eminingi kanye nokunakekelwa ngozwelo ekulweni nomdlavuza.

Ecabanga ngokuhlangenwe nakho kwakhe, uMnu. D uzwakalise ukubonga okukhulu ngokusekelwa okungaguquki kanye nobuchwepheshe bethimba lakhe lezokwelapha. "Izinga lokunakekelwa nokuzinikela engikutholile kulo lonke ukwelashwa kwami ​​​​lalingenakuqhathaniswa," ephawula. "Abagcinanga nje ngokwelapha isifo sami, kodwa futhi banakekela izidingo zami ezingokomzwelo nezokudla okunempilo, beqinisekisa ukuthi ngizizwa ngisekelwa isinyathelo ngasinye."

Indaba kaMnu. D iwubufakazi bokuqina komoya womuntu kanye nentuthuko emangalisayo eyenziwayo emkhakheni we-oncology. Njengoba siqhubeka nokuthuthukisa izindlela zokwelapha, sisalokhu sizibophezele ekuhlinzekeni ukunakekelwa komuntu ngamunye, okunesihawu, okuqondene nomuntu ngamunye osipha impilo yakhe kanye nenhlalakahle yakhe.

Ekuqaleni kwesifo kanye nosuku olulodwa ngaphambi kanye nenyanga eyodwa ngemuva kokumnika.