I-Diffuse Large B-cell Lymphoma (DLBCL)

Isiguli, owesifazane oqinile osezohlanganisa iminyaka engu-80 ubudala, sabhekana ngesibindi nokuxilongwa kwe-Diffuse Large B-cell Lymphoma (DLBCL), sabonisa isibindi esimangalisayo empini yaso nalolu hlobo lomdlavuza olunolaka.

Naphezu kokuguga kwakhe, wahlala ezimisele ukunqoba izinselele ezazibangelwa yisimo sakhe. Kodwa-ke, zingakapheli izinyanga eziyisithupha ngemuva kokuthola ukuphumula ngokwelashwa komugqa wokuqala, waphinde wabhekana nokubuyela emuva, okugcizelela isimo esibi sesifo sakhe. Naphezu kwemizamo eminingi yokwelashwa komugqa wesibili nowesithathu, umdlavuza wakhe wabonisa ukumelana okuqinile, okwabeka inselele enkulu eqenjini lakhe lezokwelapha.

Beqaphela ukuphuthuma kwesimo sakhe, ithimba lezokwelapha laqala umkhankaso wokuhlola ezinye izindlela zokwelapha. Isiguli sabhaliswa ocwaningweni lwezokwelapha oluhlola ukwelashwa kwamaseli e-CD19+22 CAR-T, indlela entsha esebenzisa amaseli e-T akhiwe ngofuzo ukuqondisa amaseli omdlavuza aveza ama-antigen athile.

Imiphumela yayimangalisa kakhulu. Inyanga eyodwa nje ngemva kokufakwa kwamaseli e-CD19+22 CAR-T, isiguli sathola ukuphulukiswa okuphelele. Lo mphumela omangalisayo awuzange nje umise ukuqhubeka kwesifo sakhe kodwa futhi waholela ekuqedweni ngempumelelo kwamaseli omdlavuza, okwaphawula isikhathi esibalulekile ohambweni lwaso lokwelashwa.

Kuyo yonke inqubo enzima, ithimba lezokwelapha lanikeza isiguli ukwesekwa nokunakekelwa okungantengantengi. Kusukela ekuqapheni ngokucophelela indlela asabela ngayo ekwelashweni kuya ekuphatheni noma yiziphi izenzakalo ezimbi, baqinisekisa ukuthi inhlalakahle yakhe ihlala iza kuqala.

Uma sicabanga ngokuhlangenwe nakho kwaso, isiguli sibonga kakhulu ngokunakekelwa ngesihawu esikutholile. "Ukuzinikela kanye nolwazi lwethimba lami lezokwelapha bekukuhle kakhulu," kusho yena. "Indlela yabo yokwelapha eyenzelwe wena yanginika ithemba ngesikhathi engisidinga kakhulu."

Umphumela ophumelelayo wokwelashwa kwamaseli e-CD19+22 CAR-T ekufinyeleleni ukuthethelelwa okuphelele uqokomisa amandla ayo njengenketho yokwelapha ethembisayo yeziguli ze-DLBCL ezingalapheki. Leli cala lisebenza njengobufakazi bamandla ezindlela zokwelapha ezintsha kanye nemithi eyenzelwe wena ekuphatheni umdlavuza oyinkimbinkimbi, ikakhulukazi ezigulini esezikhulile njengalona wesifazane onesibindi.

Ngaphambi kanye nenyanga eyodwa ngemuva kokumnika