Ukusabalalisa i-large B-cell lymphoma (DLBCL), i-NOS, uhlobo lwe-GCB, i-primary central nervous system lymphoma-01

NgoDisemba 2019, uMnu. Wang, uthisha waseNyakatho-mpumalanga yeShayina, waqala ukuba nekhanda elibuhlungu. Ngomhlaka-19 Disemba 2019, ukuhlolwa kokuxilonga kwembula okulandelayo: I-PET-CT ibonise isithunzi sobuningi obunokwanda okukhulu kwe-metabolism ye-FDG endaweni yesobunxele ye-frontal lobe kanye ne-corpus callosum knee area (cishe u-3.4 * 1.9 cm, i-SUVmax = 34.4). I-Biopsy kanye ne-immunohistochemistry kuqinisekisile ukuthi i-diffuse large B-cell lymphoma (i-DLBCL, i-NOS, i-GCB subtype), ene-immunophenotype ekhombisa i-Ki67(50%+), i-CD19(+), i-CD20(+), i-PAX5(+), i-CD79(+), i-MUM1(+), i-BCL(+), i-CD10(-/+), i-CD2(minor+). Ukuhlaziywa koketshezi lwe-cerebrospinal kwembula amaseli e-lymphoid angakavuthwa angu-6% anokuguquguquka kwesimo. Ukuxilongwa kwakuyi-primary central nervous system lymphoma (i-DLBCL, i-GCB subtype).

Ngemva kokucwaninga ngezinketho zokwelapha ku-inthanethi, uMnu. Wang wafunda ngamakhono e-BIOOCUS Medical Group immunotherapy futhi wafuna ngokushesha ubuchwepheshe babo. Ngemva kokuhlolwa okujulile ngokomzimba kanye nokuhlaziywa okucophelelayo yithimba lochwepheshe besibhedlela, kwanqunywa ukuthi uMnu. Wang uzohlanganyela esivivinyweni somtholampilo sokwelashwa kwe-CART, ikakhulukazi kusetshenziswa amaseli e-CD19 CART. Wathola ukufakwa kwamaseli e-CD19 CAR-T ngo-Ephreli 24, 2023. Ngomhlaka-30 Julayi 2023, kwahlolwa ukuthi usethole ukuxolelwa okuphelele (CR) futhi usebuyele empilweni ejwayelekile.