I-Diffuse large B-cell lymphoma (DLBCL)-04

UMnu. Li, oneminyaka engu-64 ubudala (igama elingelona iqiniso), watholakala ene-diffuse large B-cell lymphoma (DLBCL) eminyakeni emine edlule, eyayisiqhubekele ekubandakanyekeni kwe-spleen, iimbambo, amaphaphu, kanye ne-pleura esigabeni sokugcina, okubizwa ngokuthi isigaba IV. Ngemva kokwelashwa nge-immunochemotherapy yomugqa wokuqala, isimo sakhe sahlala sizinzile iminyaka engaphezu kwemithathu. Kodwa-ke, ngoMashi wonyaka odlule, isifo sakhe saphinde sabuya, sahlanganisa ama-lymph node amaningi e-retroperitoneal. Naphezu kokwelashwa nge-chemotherapy yomugqa wesibili, wathola ukuphulukiswa okungaphelele futhi washeshe wawohloka, okwadinga ukwelashwa okusebenzayo kakhulu ukulawula ukuqhubeka okuqhubekayo.

Bebhekene nale nselele enzima, ithimba lochwepheshe e-BIOOCUS Medical Group libukeze kabanzi udaba lukaMnu. Li futhi labiza umhlangano wethimba elihlanganisa imikhakha eminingi (MDT) ukuze lincome ukwelashwa kweseli le-CAR-T. Ukwelashwa kweseli le-CAR-T, njengendlela yakamuva yokwelapha nge-tumor immunotherapy, kunikeza izinzuzo ezibalulekile njengokuqondisa okuqinile kanye nokusebenza kahle okuhlala njalo kweziguli ezine-lymphoma ephinde yabuyela esimweni sayo futhi engaphikisi.

NgoJanuwari 2023, uMnu. Li welashwa nge-CAR-T cell therapy eMnyangweni weLymphoma. Ngaphambi kokwelashwa, wenziwa i-biopsy yama-lymph node angakwesokudla, okwaqinisekisa ukuthi i-CD19 ne-CD20 ziphilile, okwanikeza imigomo ecacile yokwelashwa nge-CAR-T cell. Ngaphansi kokuqondiswa kukaSolwazi Li, ithimba lezokwelapha laklama uhlelo lokwelashwa oluqondene nomuntu siqu.

Ngomhlaka-25 kuJulayi 2023, uMnu. Li waqeda inqubo yokufaka amaseli e-CD19/20 CAR-T, eyaqhubeka kahle ngaphansi kokuqashwa ngokucophelela yithimba lezokwelapha. Naphezu kokubhekana ne-cytokine release syndrome, i-cytopenia, kanye nezingozi zokutheleleka ngemuva kokufaka, ukunakekelwa okuqinile okusekelayo kuphumelele ekulawuleni ukusabela okubi ngesikhathi sokwelashwa.

Ezinyangeni eziyisithupha ngemuva kokusebenzisa ukwelashwa kwamaseli e-CAR-T, uMnu. Li akazange abonise izilonda ezisebenzayo emzimbeni wakhe wonke, okwaholela ekuphenduleni okuphelele kwe-metabolic (CMR), okwaletha ithemba elisha empilweni yakhe. Ithimba lezokwelapha laqhubeka nokwengeza izilonda ezisele ze-retroperitoneal nge-radiotherapy ukuqinisekisa ukubuyela emuva kwesifo ngokuphelele kanye nokuzinza kwesikhathi eside.

Ngale ndlela yokwelapha nge-CAR-T cell immunotherapy, uMnu. Li akagcinanga nje ngokuthola intuthuko enkulu esimweni sakhe kodwa futhi waphinde wazuza ukuzethemba kanye namandla empilweni. Icala lakhe linikeza ithemba elisha kanye nesiqondiso kubantu abane-lymphoma futhi libonisa amandla kanye nokusebenza kahle kokwelashwa nge-CAR-T cell ekwelapheni i-refractory lymphoma.

Ukwelashwa ngamaseli e-CAR-T, njengokwelashwa komdlavuza okusha, kuguqula izindlela zokuphila zeziguli ezine-refractory lymphoma. Ngaphansi kokunakekelwa okucophelelayo kwethimba lochwepheshe eMnyangweni we-Lymphoma, iziguli eziningi ezifana noMnu. Li zingalindela intuthuko enkulu ekusindeni kanye nekhwalithi yokuphila. Uma sibheka phambili, intuthuko eyengeziwe kanye nokusetshenziswa kokwelashwa ngamaseli e-CAR-T kuthembisa amathuba abanzi kanye namathuba ekwelapheni umdlavuza.