Mnu. A ----- I-Diffuse Large B-cell Lymphoma (DLBCL)

UMnu. A, odabuka eNdiya, umuntu okhuthele oneminyaka engu-66 ubudala, waqala uhambo lwakhe lwezokwelapha ngo-Ephreli 2018. Ngemva kokuhlolwa kwe-biopsy ye-mass engalweni yakhe yesobunxele, kanye ne-PET-CT scan ephelele yomzimba wonke, kwatholakala ukuthi une-Diffuse Large B-Cell Lymphoma (DLBCL). Lokhu kwaphawula ukuqala kohlelo lokwelapha oluqinile oluhlose ukulwa nalesi sifo.

Eqala ukusebenzisa imijikelezo eyisithupha iyonke yohlelo lwe-R-EPOCH chemotherapy, uMnu. A kamuva washintshela emijikelezweni emithathu yohlelo lwe-R-GDP, kwalandela eminye imijikelezo emibili efanayo. Lolu hlelo lwe-chemotherapy olunamandla lwaqala ngo-Ephreli 2018 kuya ku-Okthoba 2019, isikhathi esibonakala ngokuphikelela nokuqina lapho ubhekene nobunzima.

Naphezu kokwelashwa okunzima, kwavela ukushiyeka ngesikhathi sokuhlolwa kabusha kwe-PET-CT ngo-Okthoba 2019, okwembula ukungalingani okusha kwe-metabolic endaweni ye-calcaneus yangakwesokudla kanye ne-femur ekude kwesokudla. Engadikibali, uMnu. A, ehlome ngolwazi lokuhlukaniswa kwe-BIOOCUS Medical Group njengesikhungo se-CAR-T esihamba phambili emhlabeni jikelele, wafuna ulwazi lwayo.

UNovemba 2019 waphawula ushintsho olukhulu njengoba uMnu. A eqala isigaba esisha sokwelashwa ngaphansi kokunakekelwa kwethimba lethu lezokwelapha. Ukuhlolwa okuphelele kwembule i-CD19 encane ene-HIV kanye ne-CD22 enamandla kakhulu, okubonisa ukusebenza okuphezulu kwesimila esisele. Ngenxa yalokhu okutholakele, kwenziwa isinqumo sokuqhubeka nokwelashwa kwamaseli e-CD19+CD22 CAR-T, indlela entsha elungele ukubhekana nomdlavuza oqhubekayo.

Ngemva kokufakwa, uMnu. A waba ne-degree 2 Cytokine Release Syndrome (CRS) elawulekayo, walulama ngokushesha ngemva kwalokho. NgoJanuwari 2020, wakhishwa esibhedlela, eqiniswe yimiphumela ethembisayo evela ku-PET-CT scan yakamuva ekhombisa ukwehla kwesimila kanye nokwehla okuphawulekayo komsebenzi wokugaya ukudla.

Uhambo lukaMnu. A lusebenza njengokukhanya kwethemba, lugcizelela amandla okuguqula okungenelela kwezokwelapha okuthuthukile emkhakheni we-oncology. Njengoba eqala uhlelo lokulandelela isikhathi eside lweziguli ezingalaliswanga esibhedlela, kugxilwe ekulondolozeni amandla amasha nokuvikela ekubuyeni kwalesi sifo.