Bwana A -----Diffuse Large B-cell Lymphoma (DLBCL)

Bwana A, ukomoka mu Buhinde, akaba n'umugabo w'imyaka 66 ufite ubuzima bwiza, yatangiye urugendo rwe rw'ubuvuzi muri Mata 2018. Nyuma yo gupimwa umubiri wose mu kuboko kwe kw'ibumoso, no gupimwa umubiri wose na PET-CT, hasuzumwe Diffuse Large B-Cell Lymphoma (DLBCL). Ibi byagaragaje ko hatangiye uburyo bwo kuvura bugamije kurwanya iyi ndwara.

Nyuma yo gutangira gukoresha imiti ya chimiotherapie ya R-EPOCH inshuro esheshatu, Bwana A yaje guhindura imikorere ye ajya ku yindi myitozo itatu ya chimiotherapie ya R-GDP, hakurikiraho indi myitozo ibiri ya chimiotherapie. Iyi miti ikomeye ya chimiotherapie yatangiye kuva muri Mata 2018 kugeza mu Ukwakira 2019, igihe cyaranzwe no kwihangana no kwihangana mu gihe cy'ingorane.

Nubwo ubuvuzi bwari bugoye, habayeho ikibazo mu isuzuma rya PET-CT ryo mu Ukwakira 2019, hagaragaramo ibibazo bishya mu mikorere y’umubiri mu gace k’iburyo ka calcaneus no mu gice cy’iburyo cy’inyuma cy’ubwonko. Bwana A, wari ufite ubumenyi ku ishyirwa mu bikorwa rya BIOOCUS Medical Group nk’ikigo cya mbere cya CAR-T ku isi, yashatse ubumenyi bwacyo.

Ugushyingo 2019 byagaragaje impinduka zikomeye ubwo Bwana A yatangiraga icyiciro gishya cy’ubuvuzi yitabwaho n’itsinda ryacu ry’abaganga. Isuzuma ryimbitse ryagaragaje ko CD19 idahagije na CD22 ikomeye cyane, bigaragaza ko hari ikibyimba kinini gisigaye. Dukurikije ibyo byavumbuwe, hafashwe icyemezo cyo gukomeza gukoresha uburyo bwo kuvura CD19+CD22 CAR-T cell therapy, uburyo bugezweho bwo guhangana n’iyi kanseri idakira.

Nyuma yo guterwa, Bwana A yagize ikibazo cyo kugabanuka kwa Cytokine Release Syndrome (CRS) mu rwego rworoshye, nyuma yaho arakira vuba. Muri Mutarama 2020, yasezerewe, ahumurizwa n'ibisubizo byiza byavuye mu isuzuma rya PET-CT riheruka kugaragaza ko ikibyimba cyagabanutse ndetse n'igabanuka rikomeye ry'imikorere y'umubiri.

Urugendo rwa Bwana A rutanga icyizere, rugaragaza ubushobozi bwo guhindura uburyo bwo kuvura indwara ziteye imbere mu rwego rwa kanseri. Mu gihe yatangiye gahunda yo gukurikirana abarwayi barembye igihe kirekire, haracyari kwibanda ku gukomeza ubuzima bushya no kwirinda kongera kugaruka kw'iyi ndwara.